Search Results

Overview

Uniprot ID	A0A287APC7
Protein Name	Calcium-transporting ATPase
Gene Name	ATP2B4
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
1058	TQSLKFLKEAGHGTT
59	VNLCSRLKTNPVEGL
591	GGYRMYSKGASEIIL
735	NRLIRNEKGEVEQEK
75	GNPADLEKRKQVFGQ
766	TDKHTLVKGIIDSTV

Function

Catalyzes the hydrolysis of ATP coupled with the transport of calcium

Protein Sequence

10 MTNPTEHSLP 20 ANSIVETQEG 30 EFGCTVMDLR 40 KLMELRSTDA 50 INQINVHYGG 60 VVNLCSRLKT 70 NPVEGLSGNP 80 ADLEKRKQVF 90 GQNFIPPKKP 100 KTFLELVWEA 110 LQDVTLIILE 120 IAAIISLVLS 130 FYRPPGEENE 140 QCGLPVSSPE 150 DEGEAEAGWI 160 EGAAILFSVI 170 IVVLVTAFND 180 WSKEKQFRGL 190 QNRIEKEQKF 200 SVIRNGHIIQ 210 LPVAEIVVGD 220 IAQIKYGDLL 230 PADGILIQGN 240 DLKIDESSLT 250 GESDHVKKSL 260 ERDPMLLSGT 270 HVMEGSGRMV 280 VTAVGINSQT 290 GIIFTLLGAS 300 EGEEGEKKKK 310 GKKQGAPENR 320 NKAKTQDGVA 330 LEIQPLNSQE 340 GIDNEEKEKK 350 AAKLPKKEKS 360 VLQGKLTRLA 370 VQIGKAGLIM 380 SAITVLILIL 390 YFVIDTFVIH 400 NRPWLAECTP 410 IYVQYFVKFF 420 IIGITVLVVA 430 VPEGLPLAVT 440 ISLAYSVKKM 450 MKDNNLVRHL 460 DACETMGNAT 470 AICSDKTGTL 480 TMNRMTVVQA 490 YIGDTRYHQI 500 PSPDVLVPKV 510 LDLIVNGISI 520 NSAYTSKILP 530 PEKEGGLPRQ 540 VGNKTECALL 550 GFVTDLKQDY 560 HAVRSEVPEE 570 KLYKVYTFNS 580 VRKSMSTVIE 590 KPGGGYRMYS 600 KGASEIILRK 610 CNRILDKKGE 620 AVPFKSKDRD 630 EMVRTVIEPM 640 ACEGLRTICL 650 AYRDFNDVEP 660 LWDNESEILT 670 ELTCIAVVGI 680 EDPVRPEVPE 690 AIAKCKRAGI 700 TVRMVTGDNI 710 NTARAIATKC 720 GIVTPGDDFL 730 CLEGKEFNRL 740 IRNEKGEVEQ 750 EKLDKIWPKL 760 RVLARSSPTD 770 KHTLVKGIID 780 STVGEQRQVV 790 AVTGDGTNDG 800 PALKKADVGF 810 AMGIAGTDVA 820 KEASDIILTD 830 DNFTSIVKAV 840 MWGRNVYDSI 850 SKFLQFQLTV 860 NVVAVIVAFT 870 GACITQDSPL 880 KAVQMLWVNL 890 IMDTFASLAL 900 ATEPPTDSLL 910 KRRPYGRNKP 920 LISRTMMKNI 930 LGHAVYQLTV 940 IFFLVFAGEK 950 FFDIDSGRKA 960 PLHSPPSQHY 970 TIIFNTFVLM 980 QLFNEINSRK 990 IHGERNVFSG 1000 IFRNLIFCSV 1010 VLGTFISQIL 1020 IVEFGGKPFS 1030 CTNLTLSQWF 1040 WCLFIGIGEL 1050 LWGQVISTIP 1060 TQSLKFLKEA 1070 GHGTTKEEIT 1080 KDAEGLDEID 1090 HAEMELRRGQ 1100 ILWFRGLNRI 1110 QTQIDVINTF 1120 QTGASFKGVL 1130 KRQTMGQHLD 1140 VKHVPSSSYV 1150 TVAPVKSPPT 1160 TSVAAAVSSP 1170 TLGNQSGQSV P

Gene Ontology

Classification	GO ID	Description
Biological Process	GO:0045019	negative regulation of nitric oxide biosynthetic process
Cellular Component	GO:0045121	membrane raft
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0036126	sperm flagellum
Cellular Component	GO:0030315	T-tubule
Cellular Component	GO:0030018	Z disc
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0005516	calmodulin binding
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0050998	nitric-oxide synthase binding
Molecular Function	GO:0036487	nitric-oxide synthase inhibitor activity
Molecular Function	GO:0005388	P-type calcium transporter activity
Molecular Function	GO:0030346	protein phosphatase 2B binding
Biological Process	GO:1901660	calcium ion export
Biological Process	GO:1905145	cellular response to acetylcholine
Biological Process	GO:0071872	cellular response to epinephrine stimulus
Biological Process	GO:0030317	flagellated sperm motility
Biological Process	GO:0071878	negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway
Biological Process	GO:0016525	negative regulation of angiogenesis
Biological Process	GO:1900082	negative regulation of arginine catabolic process
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration
Biological Process	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade
Biological Process	GO:1903243	negative regulation of cardiac muscle hypertrophy in response to stress
Biological Process	GO:1902548	negative regulation of cellular response to vascular endothelial growth factor stimulus
Biological Process	GO:1903249	negative regulation of citrulline biosynthetic process
Biological Process	GO:0010629	negative regulation of gene expression
Biological Process	GO:0098736	negative regulation of the force of heart contraction
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane
Biological Process	GO:1902806	regulation of cell cycle G1/S phase transition
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II
Biological Process	GO:0051599	response to hydrostatic pressure
Biological Process	GO:0014832	urinary bladder smooth muscle contraction

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.