Overview
| Uniprot ID | A0A287APL3 |
|---|
| Protein Name | Transcriptional enhancer factor TEF-4 |
|---|
| Gene Name | TEAD2 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 67 |
YPPCGRRKIILSDEG |
Function
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif
Protein Sequence
10
MGEPRAGAPL
20
DDGSGWTGSE
30
EGSEEGTGGS
40
EGAGGDGGPD
50
AEGVWSPDIE
60
QSFQEALAIY
70
PPCGRRKIIL
80
SDEGKMYGRN
90
ELIARYIKLR
100
TGKTRTRKQV
110
SSHIQVLARR
120
KSREIQSKLK
130
ALNVDQVSKD
140
KAFQTMATMS
150
SAQLISAPSL
160
QAKLGPAGPQ
170
APELFQFWSG
180
GSGPPWNVPD
190
VKPFSQTPFS
200
LSLTPPSTDL
210
PGYEPPQTLS
220
PPALPPPAPS
230
PPAWQARALG
240
TARLQLVEFS
250
AFVEPPDAAD
260
SYQRHLFVHI
270
SQHCPSPGAP
280
PLESVDVRQI
290
YDKFPEKKGG
300
LRELYDRGPP
310
HAFFLVKFWA
320
DLNWGPSGEE
330
VGASGSSGGF
340
YGVSSQYESL
350
EHMTLTCSSK
360
VCSFGKQVVE
370
KVETERAQLE
380
DGRFVYRLLR
390
SPMCEYLVNF
400
LHKLRQLPER
410
YMMNSVLENF
420
TILQVVTNRD
430
TQELLLCTAY
440
VFEVSTSERG
450
AQHHIYRLVR
D
Gene Ontology
| Classification |
GO ID |
Description |
| Biological Process |
GO:0065003 |
protein-containing complex assembly |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0140552 |
TEAD-YAP complex |
| Cellular Component |
GO:0005667 |
transcription regulator complex |
| Molecular Function |
GO:0097718 |
disordered domain specific binding |
| Molecular Function |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function |
GO:0000978 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function |
GO:0001223 |
transcription coactivator binding |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0048568 |
embryonic organ development |
| Biological Process |
GO:0035329 |
hippo signaling |
| Biological Process |
GO:0060485 |
mesenchyme development |
| Biological Process |
GO:0007399 |
nervous system development |
| Biological Process |
GO:0045893 |
positive regulation of DNA-templated transcription |
| Biological Process |
GO:0006357 |
regulation of transcription by RNA polymerase II |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.