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Overview

Uniprot ID	A0A287APV2
Protein Name	Unconventional myosin-XVIIIa
Gene Name	MYO18A
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
1006	RRATSMRKTFTTGVA
1016	TTGVAAVKKKSLCIQ
1428	QRALQQLKKKCQRLT

Function

May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May be involved in the maintenance of the stromal cell architectures required for cell to cell contact. Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking. Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages. Strongly enhances natural killer cell cytotoxicity

Protein Sequence

10 MFNLMKKDKD 20 RDGGRKEKKE 30 KKEKKERMSA 40 AELRSLEEMG 50 LRRGFFNLNR 60 SSKRDSKTRL 70 EISNPIPIKV 80 ASGSDLHLTD 90 IDSDSNRGSV 100 ILDSGHLSTA 110 SSSDDLKGEE 120 GSLRGSVLQR 130 AAKFGSLAKQ 140 NSQMIVKRFS 150 FSQRSRDESA 160 SETSTPSEHS 170 AAPSPQVEVR 180 TLEGQLTQHP 190 GPGIPRPGPR 200 SRVPELVTKR 210 FPADLRLPPV 220 MPPPPPALRE 230 LELQRRPTGD 240 FGFSLRRTTM 250 LDRGPEGQAY 260 RRVVHFAEPG 270 AGTKDLALGL 280 VPGDRLVEIN 290 GHNVESKSRD 300 EIVEMIRQSG 310 DSVRLKVQPI 320 PELSELSRSW 330 LRSGEGPRRE 340 PAHVKTEEQI 350 AAEEAWCETE 360 KVWLVHKDGF 370 SLASQLKSEE 380 LSLPEGKVRV 390 KLDHDGTILD 400 VDEDDVEKAN 410 APPCDRLEDL 420 ASLVYLNESS 430 VLHTLRQRYG 440 ASLLHTYAGP 450 SLLVLSPRGA 460 PAVYSEKVMH 470 MFKGCRREDM 480 APHIYAVAQT 490 AYRAMLMSRQ 500 DQSIILLGSS 510 GSGKTTSCQH 520 LVQYLATIAG 530 TSGNKVFSVD 540 KWQALYTLLE 550 AFGNSPTIMN 560 GNATRFSQIL 570 SLDFDQAGQV 580 ASASIQTMLL 590 EKLRVARRPA 600 GEATFNIFYY 610 LLACGDGTLR 620 TELHLNHLAE 630 NNVFGIVPLA 640 KPEEKQKAAQ 650 QFSKLQTAMR 660 VLGISPDEQK 670 ACWLILAAIY 680 HLGAAGATKE 690 AAEAGRRQFA 700 RHEWAQKAAY 710 LLGCSLEELS 720 SAIFKHQLQA 730 STLQRSTSFR 740 QGPEESSLGD 750 STGPKLSALE 760 CLEGMASGLY 770 SELFTLLISL 780 VNRALKSSQH 790 SLCSMMIVDT 800 PGFQNPEQGG 810 SARGASFEEL 820 CHNYAQDRLQ 830 RLFHERTFVQ 840 ELERYKEENI 850 EVAFDDLEPA 860 TDDSVAAVDQ 870 ACHQSLVRSL 880 ARTDERGLLW 890 LLEEEALVPG 900 ATEDALLERL 910 FSYYGPREGD 920 KKGQSPLLRS 930 SKPHHFLLGH 940 SHGTNWVEYN 950 AAGWLSYTKQ 960 NPATQNAPRL 970 LQDSQKKIIS 980 NLFLGRAGSA 990 TVLSGSIAGL 1000 EGGSQLALRR 1010 ATSMRKTFTT 1020 GVAAVKKKSL 1030 CIQIKLQVDA 1040 LIDTIKKSKL 1050 HFVHCFLPVA 1060 EGWAGEPRSA 1070 SSRRVSSSSE 1080 LDLPPGEHCD 1090 AGLLPLDVPL 1100 LRTQLRGSRL 1110 LDAMRMYRQG 1120 YPDHMVFAEF 1130 RRRFDVLAPH 1140 LTKKHGRNYI 1150 VVDERRAVEE 1160 LLESLDLEKS 1170 SCCMGLSRVF 1180 FRAGTLARLE 1190 EQRDEQTSRN 1200 LTLFQAACRG 1210 YLARQLFKKK 1220 KIQDLAIRCV 1230 QKNIKKNKGV 1240 KDWPWWKLFT 1250 TVRPLIEVQL 1260 SEEQIRNRDE 1270 EIQQLRSKLE 1280 KVEKERNELR 1290 LSSDRLETRI 1300 SELTSELTDE 1310 RNTGESASQL 1320 LDAETAERLR 1330 AEKEMKELQT 1340 QYDALKKKME 1350 VMEMEVMEAR 1360 LIRAAEVNGE 1370 VDDEDTGGEW 1380 RLKYERAVRE 1390 VDFTKKRLQQ 1400 EFEDKLEVEQ 1410 QNKRQLERRL 1420 GDLQADSDES 1430 QRALQQLKKK 1440 CQRLTAELQD 1450 TKLHLEGQQV 1460 RNHELEKKQR 1470 RFDSELSQAH 1480 EEAQREKLQR 1490 EKLQREKDTL 1500 LAEAFSLKQQ 1510 LEEKDMDIAG 1520 FTQKVVSLEA 1530 ELQDISSQES 1540 KDEASLAKVK 1550 KQLRDLEAKV 1560 KDQEEELDEQ 1570 AGTIQMLEQA 1580 KLRLEMEMER 1590 MRQTHSKEME 1600 SRDEEVEEAR 1610 QSCQKKLKQM 1620 EVQLEEEYED 1630 KQKVLREKRE 1640 LESKLATLSD 1650 QVNQRDFESE 1660 KRLRKDLKRT 1670 KALLADAQIM 1680 LDHLKNNVPS 1690 KREIAQLKNQ 1700 LEESEFTCAA 1710 AVKARKAMEV 1720 EIEDLHLQID 1730 DIAKAKTALE 1740 EQLSRLQREK 1750 NEIQNRLEED 1760 QEDMNELMKK 1770 HKAAVAQASR 1780 DLAQMNDLQA 1790 QLEEANKEKQ 1800 ELQEKLQALQ 1810 SQVEFLEQSM 1820 VDKSLVSRQE 1830 AKIRELETRL 1840 EFERTQVKRL 1850 ESLASRLKEN 1860 MEKLTEERDQ 1870 RTAAENREKE 1880 QNKRLQRQLR 1890 DTKEEMGELA 1900 RKEAEASRKK 1910 HELEMDLESL 1920 EAANQSLQAD 1930 LKLAFKRIGD 1940 LQAAIEDEME 1950 SDENEDLINS 1960 LQDMVTKYQK 1970 RKNKPEGDSD 1980 VDSELEDRVD 1990 GVKSWLSKNK 2000 GPSKAASDDG 2010 SLKSSSPTSY 2020 WKSLAPDRSD 2030 DEHDPLDSTS 2040 RPRYTHNYLS 2050 DSDTEAKQTE TNA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0042641	actomyosin
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0000139	Golgi membrane
Cellular Component	GO:0005815	microtubule organizing center
Cellular Component	GO:0032982	myosin filament
Cellular Component	GO:0016460	myosin II complex
Cellular Component	GO:0005802	trans-Golgi network
Molecular Function	GO:0051015	actin filament binding
Molecular Function	GO:0043531	ADP binding
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0008094	ATP-dependent activity, acting on DNA
Molecular Function	GO:0003774	cytoskeletal motor activity
Molecular Function	GO:0003677	DNA binding
Biological Process	GO:0031032	actomyosin structure organization
Biological Process	GO:0090164	asymmetric Golgi ribbon formation
Biological Process	GO:0016477	cell migration
Biological Process	GO:0006259	DNA metabolic process
Biological Process	GO:0048194	Golgi vesicle budding
Biological Process	GO:0043066	negative regulation of apoptotic process
Biological Process	GO:1903028	positive regulation of opsonization
Biological Process	GO:0050714	positive regulation of protein secretion
Biological Process	GO:0043030	regulation of macrophage activation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.