Search Results
Overview
| Uniprot ID | A0A287AQ40 |
|---|---|
| Protein Name | E3 ubiquitin-protein ligase ZFP91 |
| Gene Name | ZFP91 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 125 | PRLLCTEKVSTSKDP |
| 347 | YQHLLKKKYVCPHPS |
Function
DNA-binding transcription factor. Also acts as an atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis
Protein Sequence
10
MPGETEEPRP
20
PEQQDQEGGE
30
AAAAAKAAPE
40
EPQQQPPEEA
50
AVAAPAGTTT
60
SRVLRGGRDR
70
GRAAAAAAAA
80
AAAAVSRRRK
90
AEYPRRRRSS
100
PSARPPDAPG
110
QQSQAAKPPS
120
PAQGKKSPRL
130
LCTEKVSTSK
140
DPKEEKEEDD
150
SALPQEASIA
160
ATRPSRGWRS
170
SSRTSVSRHR
180
DTENTRSSRS
190
KTGSLQLICK
200
SEPNTDQLDY
210
DVAEEHQSPG
220
GISDEEEEEE
230
EEMLISEEEI
240
PFKDDPRDET
250
YKPHLERETP
260
KPRRKSGKVK
270
EEKEKKEIKV
280
EVEVEVKEEE
290
NEIREDEEPP
300
RKRGRRRKDD
310
KSPRLPKRRK
320
KPPIQYVRCE
330
MEGCGTVLAH
340
PRYLQHHIKY
350
QHLLKKKYVC
360
PHPSCGRLFR
370
LQKQLLRHAK
380
HHTDQRDYIC
390
EYCARAFKSS
400
HNLAVHRMIH
410
TGEKPLQCEI
420
CGFTCRQKAS
430
LNWHMKKHDA
440
DSFYQFSCNI
450
CGKKFEKKDS
460
VVAHKAKSHP
470
EVLIAEALAA
480
NAGALITSTD
490
ILGTNPESLT
500
QPADGQGLPL
510
LPEPLGNSTS
520
GECLLLEAEG
530
MSKSYCSGTE
540
RVSLMADGKL
550
FVGSGSSGGT
560
EGLVMNSDIL
570
GATTEVLIED
SDSTGP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0061630 | ubiquitin protein ligase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0070534 | protein K63-linked ubiquitination |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.