Overview
| Uniprot ID | A0A287AQ96 |
|---|
| Protein Name | ADP-ribosylation factor GTPase-activating protein 1 |
|---|
| Gene Name | ARFGAP1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 226 |
SRFASAAKEGATKFG |
Function
GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine
Protein Sequence
10
MASPRTRKVL
20
KEIRVQDGNN
30
VCFECGAFNP
40
QWVSVSYGIW
50
ICLECSGRHR
60
GLGVHLSFVR
70
SVTMDKWKDA
80
ELEKMKAGGN
90
AKFQEFLESQ
100
EDYDPGWSLQ
110
EKYNSKAAAL
120
FRDKVATVAE
130
GGEWSLESSP
140
ARNWTPPRPK
150
MLPTCAHGAT
160
GRPQNSTASS
170
DKAFEDWLND
180
DLGSYQGAPE
190
NRYVGFGNTV
200
PPQKKEDDFL
210
NSAMSSLYSG
220
WSSFTTGASR
230
FASAAKEGAT
240
KFGSQASQKA
250
SELGHSLNES
260
VLKPAQEKVK
270
EGKIFDDVTS
280
GVSQLASKVQ
290
GAGSRGWRDV
300
TTFFSGRTED
310
SSDRPPEGQS
320
HQNSGGDHSQ
330
SSPFDPGFWE
340
AFGSADPAKA
350
HRSPSSDSWT
360
CADASADRRS
370
SDSWDVWGSG
380
SASNNKNSDS
390
GDGGEAWGGG
400
GEGRAKVTKK
410
AAPPPAVDEG
WDNQDW
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Molecular Function |
GO:0005096 |
GTPase activator activity |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0015031 |
protein transport |
| Biological Process |
GO:0016192 |
vesicle-mediated transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.