Search Results

Overview

Uniprot ID	A0A287AQW0
Protein Name	Myosin phosphatase Rho-interacting protein
Gene Name	MPRIP
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
938	ELSIVRAKADCDIGR
983	KSNPDFLKKDRSCVS

Function

Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells

Protein Sequence

10 MSAAKENPCR 20 KFQANIFNKS 30 KCQNCFKPRE 40 SHLLNDEDLT 50 QAKPIYGGWL 60 LLAPDGTDFD 70 NPVHRSRKWQ 80 RRFFVLYEHG 90 LLRYALDEMP 100 TTLPQGTINM 110 NQCSDVVDGE 120 ARTGQKFSLC 130 ILTPEKDHFI 140 RAETKEIISG 150 WLEMLAVYPR 160 TNKQNQKKKR 170 KVEPPTPQEP 180 GPAKVAVTSS 190 SSSIPSAEKV 200 PPTKSTLWQE 210 EMRAKDQSDG 220 SSLSPAQSPS 230 QSQPPAASTL 240 REPGLESRDE 250 ESATSSDRVD 260 GGRKVRVESG 270 YFSLEKTKQD 280 VKAEEQQLPP 290 PLSPPSPSAP 300 NTRRSQVIEK 310 FEALDIEKAE 320 HMETNASAGP 330 SPSSDTRQGR 340 SEKRAFPRKR 350 DLPSDAPLPD 360 TSASPLSPHR 370 RAKSLDRRST 380 ESSLTPDLLN 390 FKKGWLTKQY 400 EDGQWKKHWF 410 VLADQSLRFY 420 RDSVAEEAAD 430 LDGEIDLSTC 440 CDVTEYPVQR 450 NYGFQIHTKE 460 GAFTLSAMTS 470 GIRRNWIQTI 480 VKHVHPTSAP 490 DVTSSLPQEK 500 KRSSSPLETC 510 PRPRETQDGE 520 PREPDPEQKR 530 SRARERRREG 540 RSKTFDWAEF 550 RPIQQALAQE 560 RAGGAPGPPD 570 AHPEAEPGEL 580 ERERARRREE 590 RRKRAEGLGA 600 DDAALRMEVD 610 RGPGPPVTTA 620 LRTQNVHVEI 630 EQRWHQVETT 640 PLREEKQVPI 650 APLHLSSEDG 660 GDRLSTHELT 670 SLLEKELEQS 680 QKEASDLLEQ 690 NRLLQDQLRV 700 ALGREQSARE 710 GYVLQATCER 720 GFAAMEETHQ 730 KKIEDLQRQH 740 QRELEKLREE 750 KDRLLAEETA 760 ATISAIEAMK 770 NAHREEMERE 780 LEKSQRSQIS 790 SVNSDIEALR 800 RQYLEELQSV 810 QRELEVLSEQ 820 YSQKCLENAH 830 LAQALEAERQ 840 ALRQCQRENQ 850 ELNAHNQELN 860 NRLAAEISRL 870 RTLLTGDTSG 880 EAAGSPLAQG 890 KDAYELEVLL 900 RVKESEIQYL 910 KQEISSLKDE 920 LQTALRDKKY 930 ASDKYKDIYT 940 ELSIVRAKAD 950 CDIGRLKEQL 960 KAATEALGEK 970 PPENTPVAGY 980 DIMKSKSNPD 990 FLKKDRSCVS 1000 RQIRSIRSKS 1010 LKEGLTVHDR 1020 LKLFESRDLQ QD

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0015629	actin cytoskeleton
Molecular Function	GO:0051015	actin filament binding

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.