Search Results

Overview

Uniprot IDA0A287AQX9
Protein NameTight junction protein 2
Gene NameTJP2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1029 EIPGTSTKGCPPPIA
1109 ARIEIAQKHPDIYAV
123 KIAAIVVKRPRKVQM
310 GVLLMKSKANEEYGL
765 PRDAGSEKSTGVVRL

Function

Plays a role in tight junctions and adherens junctions. Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity

Protein Sequence

10 MRDPRPKMPV 20 RGDRGFPPRR 30 EMSSWLHPLM 40 EGFYFNFSLN 50 STEQDSKRGF 60 GIAVSGGRDN 70 PHFENGETSI 80 VISDVLPGGP 90 ADGLLQENDR 100 VVMVNGTPME 110 DVLHSFAVQQ 120 LRKSGKIAAI 130 VVKRPRKVQM 140 APVQGSPLIH 150 EDDRAFEVMD 160 EFDGRSARSG 170 YSERSRPSSR 180 GGRSHSWEDS 190 PERGRPHERE 200 RSRERDRSRG 210 RSLERGLDHD 220 DYGRARERSR 230 GRSLERGLDH 240 DDYGRARESS 250 RGRSIDPTYD 260 RAYSPEEEYG 270 RRAQPDARYA 280 ASRSRSHEHL 290 HSRSPSPELQ 300 GRPDQPDSDR 310 PIGVLLMKSK 320 ANEEYGLRLG 330 SQIFIKEMTR 340 TGLASKDGNL 350 HEGDIILKIN 360 GTVTENMSLT 370 DARKLIEKSR 380 GKLQLVVLRD 390 SKQTLINIPS 400 LNDSDSEVED 410 ISEIESNRSF 420 SPEERRQQYS 430 DYDYHSSNEK 440 LKERPNSRED 450 MQSRWSRMGA 460 TPTPFKSTGD 470 IAAAVSTEPS 480 KEPRYQEEAP 490 APPPKPAPRN 500 VLRPSPEDLA 510 IYGPNTKMIR 520 FKKGDSVGLR 530 LAGGNDVGIF 540 VAGIQEGTSA 550 EQEGLQEGDQ 560 ILKVNTQDFR 570 GLVREDAVLY 580 LLEIPKGEMV 590 TILAQSRADV 600 YRDILACGRG 610 DSFFIRSHFE 620 CEKETPQSLA 630 FTRGEVFRVV 640 DTLYDGKLGH 650 WLAVRIGNEL 660 EKGLIPNKSR 670 AEQMASVQTA 680 QRDSAGDRAD 690 FWRMRGQRSG 700 VKKNLRKSRE 710 DLTAVVSIST 720 KFPAYERVLL 730 REAGFKRPVV 740 LFGPIADIAM 750 EKLANELPDL 760 FQTAKTEPRD 770 AGSEKSTGVV 780 RLNTVRQIIE 790 QDKHALLDVT 800 PKAVDLLNYT 810 QWFPIVIFFN 820 PDSRQGVKTM 830 RQRLNPSSNK 840 SSRKLFDQAN 850 KLKKTCAHLF 860 TATINLNSAN 870 DSWFGSLKDT 880 IQHQQGEAVW 890 VSEGKMEGMD 900 DDPEDRMSYL 910 TAMGADYLSC 920 DSRLISDFED 930 TDGEGGAYTD 940 NELDEPAEEP 950 LVSSITRSSE 960 PVQHEESIRK 970 PSPEPRAQMR 980 RAASRDQLRD 990 NSPPPAFKPE 1000 PPKAKTANRE 1010 DSFDLSRSYE 1020 YKSNPSAVAS 1030 NEIPGTSTKG 1040 CPPPIAAKPS 1050 FGRPILKPST 1060 PVPPPESDEV 1070 GEGSEEQDGA 1080 PKSVLGKVKI 1090 FEKMDHKARL 1100 QRMQELQEAQ 1110 NARIEIAQKH 1120 PDIYAVPIKT 1130 HKPDSGLPQY 1140 ISSRPPEPQR 1150 GPARLYQDPR 1160 GSYGSDAEEE 1170 EYRQQLSEHS 1180 KRGYYGQPSR YRDTEL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005912 adherens junction
Cellular Component GO:0005923 bicellular tight junction
Cellular Component GO:0009986 cell surface
Cellular Component GO:0044291 cell-cell contact zone
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0050839 cell adhesion molecule binding
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:1990782 protein tyrosine kinase binding
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0045216 cell-cell junction organization
Biological Process GO:0090557 establishment of endothelial intestinal barrier
Biological Process GO:0034109 homotypic cell-cell adhesion
Biological Process GO:0050892 intestinal absorption
Biological Process GO:1905605 positive regulation of blood-brain barrier permeability
Biological Process GO:0150105 protein localization to cell-cell junction
Biological Process GO:0090559 regulation of membrane permeability

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.