Search Results

Overview

Uniprot IDA0A287ARA7
Protein NameProteasome adapter and scaffold protein ECM29
Gene NameECPAS
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1014 LMTGKRAKHEVSGET
1450 RYSPDVLKNHAKEVL
1701 KLMCERLKLSTWKVQ
318 GDIPLKTKEGAVLKP
697 YPEKLAAKFVDKTEW

Function

Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolysis. Promotes proteasome dissociation under oxidative stress

Protein Sequence

10 MSYPWYLIIV 20 LLPRSANQLE 30 RVFLRLGHAE 40 TDEQLQNIIS 50 KFLPPVLLKL 60 SSTQEGVRKK 70 VMELLVHLNK 80 RIKSRPKIQL 90 PVETLLVQYQ 100 DPAAVSFVTN 110 FTIIYVKMGY 120 PRLPVEKQCE 130 LAPTLLTAME 140 GKPQPQQDSL 150 MHLLIPTLFH 160 MKYPVESSKS 170 ASPFNLAEKP 180 KTVQLLLDFM 190 LDVLLMPYGY 200 VLNESQSRQN 210 SSSAQGSSSN 220 SGGGSGIPQP 230 PPGMSFYAAK 240 RVIGDNPWTP 250 EQLEQCKLGI 260 VKFIEAEQVP 270 ELEAVLHLVI 280 ASSDTRHSVA 290 TAADLELKSK 300 QSLIDWNNPA 310 IINKMYKVYL 320 GDIPLKTKEG 330 AVLKPELKRD 340 PVSTRVKLKI 350 VPHLLRSRQA 360 AETFPANIQV 370 VYDGLFGTNT 380 NSKLRTLSLQ 390 FVHHICVTCP 400 EVKIKPLGPM 410 LLNGLTKLIN 420 EYKEDPKLLS 430 MAYSAVGKLS 440 SRMPHLFTKD 450 IALVQQLFEA 460 LCKEEPETRL 470 AIQEALSMMV 480 GAYSTLEGAQ 490 RTLMEALVAS 500 YLIKPEVQVR 510 QVAVKFASTV 520 FPSDHIPSRY 530 LLLLAAGDPR 540 EEVHGEAQRV 550 LRCLPGRNRK 560 ESSSKQMPSF 570 PEMVYYIQEK 580 ASHRMKTPAK 590 YMTGTTVLPF 600 NPAAFGEIVL 610 YLRMCLAHSA 620 GVVPTSQSLA 630 DMQDHAPAIG 640 RYIRTLMSSS 650 QATSSSSSSS 660 SSKSGETNPV 670 QIYIGLLQQL 680 LAGVGGLPVM 690 YCLLEAVSVY 700 PEKLAAKFVD 710 KTEWIKSLMN 720 SSKEEMRELA 730 ALFYSVVVST 740 VSGNELKSMI 750 EQLIKTTKDN 760 HSPEIQHGSL 770 LALGFTVGRY 780 LAKKKMKMAE 790 QQGVETNADF 800 LPEQEELIQS 810 ATETIGSFLD 820 STSPLLAIAA 830 CTALGEIGRN 840 GPLPIPSEGS 850 GFTKLHLVES 860 LLNRIPSSKE 870 TNKAIKMVNE 880 LQFTIGEAIT 890 SAAIGTSSVA 900 ARDAWLVTEE 910 EYTPPAGAKV 920 NDVVPWVLDV 930 ILNKHITSPN 940 PHVRQAACIW 950 LLSLVRKLSA 960 HKEVKSHLKE 970 IQSAFVSVLS 980 ENDELSQDVA 990 SKGLGLVYEL 1000 GNEQDQQELV 1010 STLVETLMTG 1020 KRAKHEVSGE 1030 TVVFQGGSLG 1040 KTPDGQGLST 1050 YKELCSLASD 1060 LSQPDLVYKF 1070 MNLANHHAMW 1080 NSRKGAAFGF 1090 NVIATRAGEQ 1100 LAPFLPQLVP 1110 RLYRYQFDPN 1120 LGIRQAMTSI 1130 WNALVTDKSM 1140 VDKYLKEILQ 1150 DLVKNLTSNM 1160 WRVRESSCLA 1170 LNDLLRGRPL 1180 DDIIDKLPEI 1190 WETLFRVQDD 1200 IKESVRKAAE 1210 LALKTLSKVC 1220 VKMCDPAKGA 1230 AGQKTIAVLL 1240 PCLLDKGMMS 1250 PVTEVRALSI 1260 NTLVKISKSA 1270 GAMLKPHAPK 1280 LIPALLESLS 1290 VLEPQVLNYL 1300 SLRATDQEKA 1310 AMDSARLSAA 1320 KSSPMMETIN 1330 MCLQYLDVSV 1340 LGELVPRLCE 1350 LIRSGVGLGT 1360 KGGCASVIVS 1370 LTTQCPQDLT 1380 PYSGKLMSAL 1390 LSGLTDRNSV 1400 IQKSCAFAMG 1410 HLVRTSRDSS 1420 TEKLLQKLNG 1430 WYMEKEEPVY 1440 KTSCALTVHA 1450 IGRYSPDVLK 1460 NHAKEVLPLA 1470 FLGMHEIADE 1480 EKAEKEECNL 1490 WTEVWQENVP 1500 GSFGGIRLYL 1510 QELITIAQKA 1520 LQSQSWKMKA 1530 QGAIAMASIA 1540 KQTSSLVPPY 1550 LGMILTALLQ 1560 GLAGRTWAGK 1570 EELLKAIACV 1580 VTACSAELEK 1590 PVPNQPSINE 1600 ILQAVLKECG 1610 KENPKYKIVA 1620 ISCTADVLKA 1630 TKEDRFQEFA 1640 DIVIPLIKKN 1650 SPESIGVRTS 1660 KNEDENEKEK 1670 ELQLESLLGA 1680 FESLGKAWPR 1690 NVETQRCYRQ 1700 ELCKLMCERL 1710 KLSTWKVQLG 1720 VLQSMNAFFQ 1730 GLMLLEEEHA 1740 DPEALAEILL 1750 ETCKSITYSL 1760 ENKTYSSVRT 1770 EALSVIELLL 1780 KKLEESKQWE 1790 SLTSECRVLL 1800 IESLATMETD 1810 SRPELQEKAS 1820 LLKKTLENLE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Cellular Component GO:0030134 COPII-coated ER to Golgi transport vesicle
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005769 early endosome
Cellular Component GO:0030139 endocytic vesicle
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
Cellular Component GO:0005771 multivesicular body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000502 proteasome complex
Molecular Function GO:0060090 molecular adaptor activity
Molecular Function GO:0070628 proteasome binding
Biological Process GO:0036503 ERAD pathway
Biological Process GO:0043248 proteasome assembly

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.