Search Results
Overview
| Uniprot ID | A0A287ARS0 |
|---|---|
| Protein Name | Sphingosine-1-phosphate lyase 1 |
| Gene Name | SGPL1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 369 | SVVLYSDKKYRNYQF |
| 425 | EATKQIIKTTRFLKA |
| 431 | IKTTRFLKAELENIK |
Function
Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP. Seems to play a role in establishing neuronal contact sites and axonal maintenance
Protein Sequence
10
MPSTDLLMLK
20
AFEPYFEILE
30
VYSTKAKNYV
40
NGHCTKYEPW
50
QLIAWSVVWT
60
LLIVWVYKFV
70
FQPESLWSRF
80
KKRCVKLIRK
90
MPVIGRKIQD
100
KLNKTKDDIS
110
KNMSFLKVDK
120
EYVKALPSQG
130
LSPAAVLEKL
140
KEYSSLDVSW
150
QEGKASGAVY
160
SGEKELTELL
170
VKAYGDFAWS
180
NPLHPDIFPG
190
LRKIEAEIVR
200
MACSLFNGGP
210
DSCGCVTSGG
220
TESILMACKA
230
YRELAFENGI
240
KTPEIVAPQS
250
AHAAFDKAAN
260
YFGMKIIRVP
270
LNKMMEVDIR
280
AMRRAISRNT
290
AMLVCSTPQY
300
PHGVIDPVPE
310
VAKLAVKYKI
320
PLHVDACLGG
330
FLIVFMEKAG
340
YPLEQPFDFR
350
VKGVTSISAD
360
THKYGYAPKG
370
SSVVLYSDKK
380
YRNYQFFVAT
390
DWQGGIYASP
400
TMAGSRPGGI
410
SAACWAALMY
420
FGENGYVEAT
430
KQIIKTTRFL
440
KAELENIKGI
450
FVFGNPQLSV
460
IALGSRDFDI
470
FRLFNLMTAK
480
GWNLNQLQFP
490
PSIHFCITLV
500
HTRKRVAIQF
510
LKDIRESVTQ
520
IMKNPKAKTT
GMVLVGV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Molecular Function | GO:0030170 | pyridoxal phosphate binding |
| Molecular Function | GO:0008117 | sphinganine-1-phosphate aldolase activity |
| Biological Process | GO:0019752 | carboxylic acid metabolic process |
| Biological Process | GO:0006665 | sphingolipid metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.