Search Results
Overview
| Uniprot ID | A0A287ARU4 |
|---|---|
| Protein Name | S-phase kinase-associated protein 1 |
| Gene Name | SKP1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 132 | VANMIKGKTPEEIRK |
| 157 | EEEAQVRKENQWCEE |
Function
Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1
Protein Sequence
10
MSMPSIKLQS
20
SDGEIFEVDV
30
EIAKQSVTIK
40
TMLEDLGMDD
50
EGDDDPVPLP
60
NVNAAILKKV
70
IQWCTHHKDD
80
PPPPEDDENK
90
EKRTDDIPVW
100
DQEFLKVDQG
110
TLFELILAAN
120
YLDIKGLLDV
130
TCKTVANMIK
140
GKTPEEIRKT
150
FNIKNDFTEE
160
EEAQVRKENQ
WCEEK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0031467 | Cul7-RING ubiquitin ligase complex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0031519 | PcG protein complex |
| Cellular Component | GO:0019005 | SCF ubiquitin ligase complex |
| Molecular Function | GO:0008013 | beta-catenin binding |
| Molecular Function | GO:0097602 | cullin family protein binding |
| Molecular Function | GO:1990444 | F-box domain binding |
| Molecular Function | GO:1990757 | ubiquitin ligase activator activity |
| Molecular Function | GO:0160072 | ubiquitin ligase complex scaffold activity |
| Molecular Function | GO:1990756 | ubiquitin-like ligase-substrate adaptor activity |
| Biological Process | GO:0006338 | chromatin remodeling |
| Biological Process | GO:0051457 | maintenance of protein location in nucleus |
| Biological Process | GO:0070936 | protein K48-linked ubiquitination |
| Biological Process | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.