Overview
| Uniprot ID | A0A287ARV5 |
|---|
| Protein Name | Ubiquitin-related modifier 1 |
|---|
| Gene Name | URM1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 24 |
LLFDGVKKHQVTLPG |
| 46 |
RNLLVWIKKNLLKER |
Function
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates
Protein Sequence
10
MAAPLSVEVE
20
FGGGAELLFD
30
GVKKHQVTLP
40
GQDEPWDVRN
50
LLVWIKKNLL
60
KERPELFIQG
70
DSVRPGILVL
80
INDADWELLG
90
ELDYQLQDQD
100
SILFISTLGV
110
ARPSAVPLGP
120
ASRSSCPPWR
130
FSSLVCPLRS
140
LQAGKRGQVL
150
KMSLLRHVSR
160
GRLSRGRCPS
170
VCQEWGGLCS
180
QVITQLLSAP
190
LPPRVSAHTP
200
SHHSRAAGPC
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0031386 |
protein tag activity |
| Biological Process |
GO:0032447 |
protein urmylation |
| Biological Process |
GO:0034227 |
tRNA thio-modification |
| Biological Process |
GO:0002098 |
tRNA wobble uridine modification |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.