Search Results
Overview
| Uniprot ID | A0A287ARZ1 |
|---|---|
| Protein Name | Thioredoxin domain-containing protein 5 |
| Gene Name | TXNDC5 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 117 | DARVYVAKVDCTAHS |
| 142 | YPTLKLFKPGQEAVK |
| 149 | KPGQEAVKYQGPRDF |
| 243 | SATVKIGKVDCTQHY |
| 365 | IWEQLSRKEFPGLAG |
| 374 | FPGLAGVKIAEVDCT |
| 389 | AERDLCSKYSVRGYP |
Function
Protein disulfide isomerase of the endoplasmic reticulum lumen involved in the formation of disulfide bonds in proteins. Can reduce insulin disulfide bonds
Protein Sequence
10
MPACPGRLLP
20
PRPRALAPAA
30
PPLPLLGGGG
40
GGHWGVRAQE
50
PGAAAAGPPA
60
AEGEDGQDPH
70
AKHLYTADMF
80
THGIQSAAHF
90
VMFFAPWCGH
100
CQRLQPTWND
110
LGDKYNSMED
120
ARVYVAKVDC
130
TAHSELCSAQ
140
GVRGYPTLKL
150
FKPGQEAVKY
160
QGPRDFKTLE
170
NWMLQTLDEA
180
PPTSEPEAEP
190
PRAPELKQGL
200
YELSASNFEL
210
HVAQGDHFIK
220
FFAPWCGHCK
230
ALAPTWEQLA
240
LGLEHSATVK
250
IGKVDCTQHY
260
ELCSGNQVRG
270
YPTLLWFRDG
280
KKVDQYKGKR
290
DLDSLREYVQ
300
AQLQSAGPGT
310
PETAQPSEAP
320
APATEPAAEQ
330
GAVLALTEDN
340
FDDTVAEGVT
350
FIKFYAPWCG
360
HCKNLAPIWE
370
QLSRKEFPGL
380
AGVKIAEVDC
390
TAERDLCSKY
400
SVRGYPTLLL
410
FRGGKKVGEH
420
SGGRDLDSLH
430
RFVLRQAKDE
L
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Molecular Function | GO:0003756 | protein disulfide isomerase activity |
| Molecular Function | GO:0015035 | protein-disulfide reductase activity |
| Biological Process | GO:0006457 | protein folding |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.