Overview
| Uniprot ID | A0A287ASJ9 |
|---|
| Protein Name | Cyclin-dependent kinase 14 |
|---|
| Gene Name | CDK14 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 146 |
NGKLVALKVIRLQEE |
Function
Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport
Protein Sequence
10
MHGYFGCNAA
20
AEPGYSAFLG
30
TPQICVTKMS
40
TRNCPGMDSM
50
IKPLDTIPED
60
KKVRVQRTQS
70
TFDPFEKPAN
80
QVKRVHSENN
90
ACINFKTSSA
100
GKESPKVRRH
110
SSPSSPTSPK
120
FGKADSYEKL
130
EKLGEGSYAT
140
VYKGKSKVNG
150
KLVALKVIRL
160
QEEEGTPFTA
170
IREASLLKGL
180
KHANIVLLHD
190
IIHTKETLTL
200
VFEYVHTDLC
210
QYMDKHPGGL
220
HPENVKLFLF
230
QLLRGLSYIH
240
QRYILHRDLK
250
PQNLLISDTG
260
ELKLADFGLA
270
RAKSVPSHTY
280
SNEVVTLWYR
290
PPDVLLGSTE
300
YSTCLDMWGV
310
GCIFVEMIQG
320
VAAFPGMKDI
330
QDQLERIFLV
340
LGTPNEDTWP
350
GVHSLPHFKP
360
ERFTLYSSKN
370
LRQAWNKLSY
380
VNHAEDLASK
390
LLQCSPKNRL
400
SAQAALSHEY
410
FSDLPPRLWE
420
LTDMSSIFTV
430
PNVRLQPEAG
440
ESTRAFGKNN
450
SYGKSLSNSK
H
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0004693 |
cyclin-dependent protein serine/threonine kinase activity |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0016055 |
Wnt signaling pathway |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.