Search Results

Overview

Uniprot IDA0A287ASV9
Protein NameExtended synaptotagmin-1
Gene NameESYT1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
187 TRVELGEKPLRILGV
195 PLRILGVKVHPGQRK
229 EVKKYFCKAGVKGMQ
347 SSKDKYVKGLIEGKS
353 VKGLIEGKSDPYALV
491 RAQDLPLKKGNKEPN
647 RFLGGLVKGKSDPYV
655 GKSDPYVKLKLAGRS

Function

Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Acts as an inhibitor of ADGRD1 G-protein-coupled receptor activity in absence of cytosolic calcium. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport

Protein Sequence

10 MERSPGDRSS 20 PVDQPYAPSD 30 PPDQPPVAPT 40 KPDQSSGNQP 50 AGPGAAGEAL 60 AVLTSFGRRL 70 LVLVPVYLAG 80 AMGLSVGFVL 90 FGLALYLGWR 100 RVREEKERSL 110 RVAQQLLEDE 120 ERLTAKTLYM 130 SQRELPAWVS 140 FPDVEKAEWL 150 NKIVAQVWPF 160 LGQYMEKLLA 170 ETVAPAVRGS 180 NPHLQTFTFT 190 RVELGEKPLR 200 ILGVKVHPGQ 210 RKEQILLDLN 220 ISYVGDVQID 230 VEVKKYFCKA 240 GVKGMQLHGV 250 LRVILEPLIG 260 DLPIVGAVSM 270 FFIRRPTLDI 280 NWTGMTNLLD 290 IPGLSSLSDT 300 MIMDSIAAFL 310 VLPNRLLVPL 320 VPDLQDVAQL 330 RSPLPRGIIR 340 VHLLAARGLS 350 SKDKYVKGLI 360 EGKSDPYALV 370 RVGTQAFCSR 380 VIDEELNPQW 390 GETYEVMVHE 400 VPGQEIEVEV 410 FDKDPDKDDF 420 LGRMKLDVGK 430 VLQAAVMDEW 440 FPLQGGQGQV 450 HLRLEWLSLL 460 PDAEKLEQIL 470 QWNRGVSSRP 480 EPPSAAILVV 490 YLDRAQDLPL 500 KKGNKEPNPM 510 VQLSVQDVTQ 520 ESKAVYSTNS 530 PVWEEAFRFF 540 LQDPRSQELD 550 VQVKDDSRAL 560 TLGALTLPLA 570 RLLTAPELTL 580 DQWFQLSKVR 590 FPAGPGTPEA 600 WDLDNESPQT 610 GSSVDTPPRP 620 SHTTPDSNFG 630 TENVLRIHVL 640 EAQDLIAKDR 650 FLGGLVKGKS 660 DPYVKLKLAG 670 RSFRSRVIRE 680 DLNPHWNEVF 690 EVIVTSIPGQ 700 ELEAEVFDKD 710 LDKDDFLGRC 720 KVSLTTVLNS 730 GFLDEWLTLE 740 DVPSGRLHLR 750 LERLTPRPTA 760 AELEEVLQVN 770 SLIQTQKSAE 780 LAAALLSVYL 790 ERAEDLPLRK 800 GTKPPSPYAT 810 LAVGETSHKT 820 KTVPQTSAPI 830 WDESASFLIR 840 KPNIESLELQ 850 VRGEGTGVLG 860 SLSLPLSELL 870 VADRLCLDRW 880 FTLSSGQGQV 890 LLRAQLGILV 900 SQHSGVEAHS 910 HSHSSSSLSE 920 EPELWGGLPH 930 VTSSAPELRQ 940 RLTHGDSPQE 950 APAGPLGQVK 960 LTVWYYSEER 970 KLVSMVHSCR 980 ALRQNGRDPP 990 DPYVSLLLLP 1000 DKNRGTKRKT 1010 SQKKRTLNPE 1020 FNERFEWELP 1030 LDEALRRKLD 1040 VSVKSSSSFM 1050 SRERELLGKV 1060 RGQGGQGQGR VRSCQWQGL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0008289 lipid binding
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0061817 endoplasmic reticulum-plasma membrane tethering
Biological Process GO:0006869 lipid transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.