Overview
| Uniprot ID | A0A287AT16 |
|---|
| Protein Name | COP9 signalosome complex subunit 1 |
|---|
| Gene Name | GPS1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 140 |
KALLKLEKLDTDLKN |
| 154 |
NYKGNSIKESIRRGH |
| 243 |
QTQAILTKLKCAAGL |
| 245 |
QAILTKLKCAAGLAE |
| 417 |
ARIDSHSKILYARDV |
Function
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction
Protein Sequence
10
MPLPVQVFNL
20
QGAVEPMQID
30
VDPQEDPQNA
40
PDVNYVVENP
50
TLDLEQYAAS
60
YSGLMRIERL
70
QFIADHCPPL
80
RAEALKMALS
90
FVQRTFNVDM
100
YEEIHRKLSE
110
ATRELQNTPD
120
AIPESGVEPP
130
PLDTAWVEAT
140
RKKALLKLEK
150
LDTDLKNYKG
160
NSIKESIRRG
170
HDDLGDHYLD
180
CGDLSNALKC
190
YSRARDYCTS
200
AKHVINMCLN
210
VIKVSVYLQN
220
WSHVLSYVSK
230
AESTPEIAER
240
GERDTQTQAI
250
LTKLKCAAGL
260
AELAARKYKQ
270
AAKCFLLAAF
280
DHCDFPELLS
290
PSNVAVYGGL
300
CALATFDRQE
310
LQRNVISSSS
320
FKLFLELEPQ
330
VRDIIFKFYE
340
SKYASCLKML
350
DEMKDNLLLD
360
MYLAPHVRTL
370
YTQIRNRALI
380
QYFSPYVSAD
390
MRKMATAFNT
400
TVAALEDELT
410
QLILEGLINA
420
RIDSHSKILY
430
ARDVDQRSTT
440
FEKSLLMGKE
450
FQRRVKAMIL
460
RAAVLRNQIH
470
VKSPPREGSQ
480
GELTPANSQS
RMSTNM
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0008180 |
COP9 signalosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.