Search Results
Overview
| Uniprot ID | A0A287AT41 |
|---|---|
| Protein Name | Signal peptidase complex subunit 2 |
| Gene Name | SPCS2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 100 | SLKRFDDKYTLKLTF |
| 122 | QREAEFTKSIAKFFD |
| 38 | SRSGLLDKWKIDDKP |
| 40 | SGLLDKWKIDDKPVK |
| 50 | DKPVKIDKWDGSAVK |
Function
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site
Protein Sequence
10
MAAAAAQGGR
20
SGGGGGSSGA
30
GGGPSCGTGS
40
SRSGLLDKWK
50
IDDKPVKIDK
60
WDGSAVKNSL
70
DDSAKKEKSI
80
FLVAHRKDPT
90
GMDPDDIWQL
100
SSSLKRFDDK
110
YTLKLTFISG
120
RTKQQREAEF
130
TKSIAKFFDH
140
SGTLVMDAYE
150
PEISRLHDSL
ATERKIK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005787 | signal peptidase complex |
| Molecular Function | GO:0008233 | peptidase activity |
| Biological Process | GO:0006465 | signal peptide processing |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.