Search Results

Overview

Uniprot IDA0A287ATC4
Protein NamePre-mRNA-processing factor 6
Gene NamePRPF6
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
429 KKARLLLKSVRETNP
946 EAYNQGLKKCPHSTP

Function

Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation

Protein Sequence

10 MHRVHAVSRA 20 APAQGLRFPR 30 VQTANRGLIE 40 GDTARPPAAT 50 RAGAPRACAY 60 RVSVSESRSR 70 RKRAEVAFRE 80 LPVGAAEVGG 90 DLSVRALCFR 100 GAGDAGARAL 110 PAAALRSSVV 120 FGLRPQPPSF 130 PFPAVGVTAA 140 MNKKKKPFLG 150 MPAPLGYVPG 160 LGRGATGFTT 170 RSDIGPARDA 180 NDPVDDRHAP 190 PGKRTVGDQM 200 KKSQAADDDD 210 EDLNDTNYDE 220 FNGYAGSLFS 230 SGPYEKDDEE 240 ADAIYAALDK 250 RMDERRKERR 260 EQREKEEIEK 270 YRMERPKIQQ 280 QFSDLKRKLA 290 EVTEEEWLSI 300 PEVGDARNKR 310 QRNPRYEKLT 320 PVPDSFFAKH 330 LQTGENHTSV 340 DPRQTQFGGL 350 NTPYPGGLNT 360 PYPGGMTPGL 370 MTPGTGELDM 380 RKIGQARNTL 390 MDMRLSQVSD 400 SVSGQTVVDP 410 KGYLTDLNSM 420 IPTHGGDIND 430 IKKARLLLKS 440 VRETNPHHPP 450 AWIASARLEE 460 VTGKLQVARN 470 LIMKGTEMCP 480 KSEDVWLEAA 490 RLQPGDTAKA 500 VVAQAVRHLP 510 QSVRIYIRAA 520 ELETDIRAKK 530 RVLRKALEHV 540 PNSVRLWKAA 550 VELEEPEDAR 560 IMLSRAVECC 570 PTSVELWLAL 580 ARLETYENAR 590 KVLNKARENI 600 PTDRHIWITA 610 AKLEEANGNT 620 QMVEKIIDRA 630 ITSLRANGVE 640 INREQWIQDA 650 EECDKAGSVA 660 TCQAVMRAVI 670 GIGIEEEDRK 680 HTWMEDADSC 690 VAHNALECAR 700 AIYAYALQVF 710 PSKKSVWLRA 720 AYFEKNHGTR 730 ESLEALLQRA 740 VAHCPKAEVL 750 WLMGAKSKWL 760 AGDVPAARSI 770 LALAFQANPN 780 SEEIWLAAVK 790 LESENNEYER 800 ARRLLAKARS 810 SAPTARVSRA 820 APPPASGAGG 830 GTEAAGTRSW 840 LGALSFAVQS 850 CVWPGPFQGA 860 GARLQQRVRA 870 AGWTARGVSR 880 GRARPGRCCL 890 TPSPQVFMKS 900 VKLEWVLGNL 910 AAAQELCEEA 920 LKHYEDFPKL 930 WMMKGQIEEQ 940 EELMEKAREA 950 YNQGLKKCPH 960 STPLWLLLSR 970 LEEKIGQLTR 980 ARAILEKSRL 990 KNPKNPGLWL 1000 ESVRLEYRAG 1010 LKNIASTLMA 1020 KALQECPSSG 1030 VLWSEAIFLE 1040 ARPQRKTKSV 1050 DALKKCEHDP 1060 HVLLAVAKLF 1070 WSERKITKAR 1080 EWFHRTVKID 1090 SDLGDAWAFF 1100 YKFELQHGTE 1110 EQREEVRRRC 1120 ENAEPRHGEL 1130 WCATSKDITN 1140 WQRKIGEILV 1150 LVAARIRNPF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0071013 catalytic step 2 spliceosome
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0071005 U2-type precatalytic spliceosome
Cellular Component GO:0046540 U4/U6 x U5 tri-snRNP complex
Cellular Component GO:0005682 U5 snRNP
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Molecular Function GO:0043021 ribonucleoprotein complex binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0000398 mRNA splicing, via spliceosome
Biological Process GO:0000244 spliceosomal tri-snRNP complex assembly

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.