Search Results
Overview
| Uniprot ID | A0A287ATJ4 |
|---|---|
| Protein Name | Alpha-crystallin B chain |
| Gene Name | CRYAB |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 154 | SPEELKVKVLGDVIE |
Function
May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome
Protein Sequence
10
MRRRLRSEVR
20
PQQSQRDPSS
30
CRRRARLSEY
40
WKLHKTAYIR
50
GWLELQLKEL
60
TGQLTLYIHP
70
AAMDIAIHHP
80
WIRRPFFPFH
90
SPSRLFDQFF
100
GEHLLESDLF
110
PASTSLSPFY
120
FRPPSFLRAP
130
SWIDTGLSEM
140
RLEKDRFSVN
150
LDVKHFSPEE
160
LKVKVLGDVI
170
EVHGKHEERQ
180
DEHGFISREF
190
HRKYRIPADV
200
DPLTITSSLS
210
SDGVLTVNGP
220
RRQASGPERT
230
IPITREEKPA
VTAAPKK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0001540 | amyloid-beta binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0005212 | structural constituent of eye lens |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:1905907 | negative regulation of amyloid fibril formation |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0032387 | negative regulation of intracellular transport |
| Biological Process | GO:0031333 | negative regulation of protein-containing complex assembly |
| Biological Process | GO:0050821 | protein stabilization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.