Search Results

Overview

Uniprot IDA0A287ATN5
Protein NameMonofunctional C1-tetrahydrofolate synthase, mitochondrial
Gene NameMTHFD1L
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
349 RWKLHCLKLQPLSPV
369 ISRAQTPKAVDVLAK
531 NGIREFSKIQLARLK

Function

May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism complementing thus the enzymatic activities of MTHFD2

Protein Sequence

10 MSARLPLLLR 20 QLRSPQLPGR 30 PRLLRALCRA 40 SSGGGGGCGG 50 GEAPLGQQRL 60 RDSQAGSSRG 70 PGSRAPPARD 80 SIVREVIQNS 90 KEVLSLLQEK 100 NPAFKPVLAV 110 IQAGEDNLMQ 120 EINQKLAEEA 130 GLNITHICLP 140 ADSSEDEIID 150 EILKINEDSR 160 VHGLALQISE 170 TSFSSKILHA 180 LKPEKDVDGV 190 TDVNLGKLVR 200 GDAHDCFVSP 210 VARAVIELLE 220 KSGVNLDGRK 230 ILVIGAHGSL 240 EATLQCLFQR 250 KGSMTMSSQW 260 KAPQLQSKLH 270 EADVVIFGSP 280 KPEEVPLSWI 290 QQGTAVLNCS 300 HDFLSGKLGC 310 SSPGIHGHSL 320 IAEDVSLLAA 330 ALRIQNMVGS 340 GRRWLREQQY 350 RRWKLHCLKL 360 QPLSPVPSDI 370 EISRAQTPKA 380 VDVLAKEIGL 390 LEDEIEIYGR 400 SKAKVRLSLL 410 ERLKDQADGK 420 YVLVAGITPT 430 PLGEGKSTVT 440 IGLVQAMTAH 450 LNVNSFACLR 460 QPSQGPTFGV 470 KGGAAGGGYA 480 QVIPMEEFNL 490 HLTGDIHAIT 500 AANNLLAAAI 510 DTRILHENTQ 520 TDKALYNRLV 530 PSVNGIREFS 540 KIQLARLKKL 550 GINKTDPSAL 560 TEDEMRKFAR 570 LDIDPATITW 580 QRGGCWCPGG 590 RMAHGNTEKG 600 HSRQAQFDIA 610 VASEIMAVLA 620 LTDSLKDMKE 630 RLGRMVVASD 640 KNGQPVTADD 650 LGVTGALTVL 660 MKDAIKPNLM 670 QTLEGTPVFV 680 HAGPFANIAH 690 GNSSVLADKI 700 ALKLVGEEGF 710 VVTEAGFGAD 720 IGMEKFFNIK 730 CRASGLVPNV 740 VVLVATVRAL 750 KMHGGGPSVT 760 AGVPLKKEYT 770 EENLQLVADG 780 CCNLKKQIQI 790 AQLFGVPVVV 800 ALNVFKTDTR 810 AEIDLVCELA 820 KQAGAFDAVP 830 CYHWSVGGKG 840 SVDLAWAVSE 850 AAHKGSRFQF 860 LYDVQLPIVE 870 KIRTIAQAVY 880 GARDIELSSE 890 AQSKIDRYTE 900 QGFGNLPICM 910 AKTHLSLSHQ 920 PDKKGVPKDF 930 ILPITDVRAS 940 IGAGFIYPLV 950 GTMSTMPGLP 960 TRPCFYDIDL 970 DTETEQVQGL F

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004329 formate-tetrahydrofolate ligase activity
Molecular Function GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity
Molecular Function GO:0042803 protein homodimerization activity
Biological Process GO:0009257 10-formyltetrahydrofolate biosynthetic process
Biological Process GO:0048702 embryonic neurocranium morphogenesis
Biological Process GO:0048703 embryonic viscerocranium morphogenesis
Biological Process GO:0015943 formate biosynthetic process
Biological Process GO:0001843 neural tube closure
Biological Process GO:0035999 tetrahydrofolate interconversion

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.