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Overview

Uniprot IDA0A287AU26
Protein NamePolypyrimidine tract-binding protein 1
Gene NamePTBP1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
132 YIQFSNHKELKTDSS
135 FSNHKELKTDSSPNQ
257 TLRIDFSKLTSLNVK
264 KLTSLNVKYNNDKSR
392 YGDVQRVKILFNKKE
434 PVRITLSKHQNVQLP
452 QEDQGLTKDYGNSPL
509 GGIVKGFKFFQKDRK

Function

Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform

Protein Sequence

10 GIVPDIAVGT 20 KRGSDELFSA 30 CVTNGPFIMS 40 SNSASTANGN 50 DSKKFKGDNR 60 SAGVPSRVIH 70 IRKLPSDVTE 80 GEVISLGLPF 90 GKVTNLLMLK 100 GKNQAFIEMN 110 TEEAANTMVN 120 YYTSVTPVLR 130 GQPIYIQFSN 140 HKELKTDSSP 150 NQARAQAALQ 160 AVNSVQSGNL 170 ALAASAAAVD 180 AGMAMAGQSP 190 VLRIIVENLF 200 YPVTLDVLHQ 210 IFSKFGTVLK 220 IITFTKNNQF 230 QALLQYADPV 240 SAQHAKLSLD 250 GQNIYNACCT 260 LRIDFSKLTS 270 LNVKYNNDKS 280 RDYTRPDLPS 290 GDNQPSLDQT 300 MAAAFGAPGI 310 MSASPYAGAG 320 FPPTFAIPQA 330 AGLSVPNVHG 340 ALAPLAIPSA 350 AAAAAAAGRI 360 AIPGLAGAGN 370 SVLLVSNLNP 380 ERVTPQSLFI 390 LFGVYGDVQR 400 VKILFNKKEN 410 ALVQMADGSQ 420 AQLAMSHLNG 430 HKLHGKPVRI 440 TLSKHQNVQL 450 PREGQEDQGL 460 TKDYGNSPLH 470 RFKKPGSKNF 480 QNIFPPSATL 490 HLSNIPPSIS 500 EEDLKILFSS 510 NGGIVKGFKF 520 FQKDRKMALI 530 QMGSVEEAIQ 540 ALIDLHNHDL 550 GENHHLRVSF SKSTI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006397 mRNA processing
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:1903312 negative regulation of mRNA metabolic process
Biological Process GO:0008380 RNA splicing

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.