Search Results
Overview
| Uniprot ID | A0A287AUH4 |
|---|---|
| Protein Name | Eukaryotic translation initiation factor 2A |
| Gene Name | EIF2A |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 192 | AVYVPGSKGAPSFVR |
| 350 | VWDVKNYKLISKPVA |
Function
Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner
Protein Sequence
10
MAPSAPLLTV
20
RGSEGLYLVN
30
GPPHFTESTV
40
FPRESGKNCK
50
AYTFSKDGTL
60
FAWGNGERIN
70
VINVTTKELL
80
HSFDLPKAVC
90
LEFSPKNTIL
100
ATWQPYTTSK
110
DGAAGIPNLQ
120
LYDMKTGTCL
130
KSFIQKKMQN
140
WCPSWSEDET
150
LCARNVNNEV
160
HFFENNNFNT
170
IANKLHLKKI
180
NDFVLSPGPQ
190
PYKVAVYVPG
200
SKGAPSFVRL
210
YQYPNFDGPH
220
AALANKSFFK
230
ADKVTMLWNK
240
KATAVLVIAS
250
TEVDKTGASY
260
YGEQTLHYIA
270
TNGESAVVQL
280
PKNGPIYDVV
290
WNSSSTEFCA
300
VYGFMPAKAT
310
IFNLKCDPVF
320
DFGTGPRNAA
330
YYSPHGHILV
340
LAGFGNLRGQ
350
MEVWDVKNYK
360
LISKPVASDS
370
TYFAWCPDGE
380
HILTATCAPR
390
LRVNNGYKIW
400
HYTGSVLHKY
410
DVPSNAELWQ
420
VSWQPFLDGI
430
FPEKSITYQA
440
VPSDVPSEEP
450
KVATAYRPPA
460
LRNKPVTNSK
470
LHEEEPPQNM
480
KPQPGNEKPL
490
SKTALKNQRK
500
HEAKKAAKQE
510
ARSDKSPDMA
520
PSPAPQNTPR
530
NTVSHSTSGD
540
PEIDKKIKNL
550
KKKLKAIEQL
560
KEQAATGKQL
570
EKNQLEKIQK
580
EKALLQELED
LELGI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005850 | eukaryotic translation initiation factor 2 complex |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0043022 | ribosome binding |
| Molecular Function | GO:0003743 | translation initiation factor activity |
| Molecular Function | GO:0000049 | tRNA binding |
| Biological Process | GO:0006417 | regulation of translation |
| Biological Process | GO:0006413 | translational initiation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.