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Overview

Uniprot ID	A0A287AV25
Protein Name	Thimet oligopeptidase
Gene Name	THOP1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
158	LPKETQEKIKSIKKK
224	PHYFPLLKKCHVPET
234	HVPETRRKVEEAFNC
244	EAFNCRCKEENCAIL
401	VRDAASGKVIGKFYL

Function

Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments. Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1

Protein Sequence

10 ACAGDALDVA 20 APCSAVNYLR 30 WDLSAQQIGE 40 LTTELIEQTK 50 RVYDRVGTQE 60 LQDVSYENTL 70 KALADVEVSY 80 TVQRNILDFP 90 QHVSPCKDIR 100 TASTEADKKL 110 SEFDVEMSMR 120 QDVYQRIVWL 130 QEKVQKDSLR 140 PEAARYLERL 150 IKLGRRNGLH 160 LPKETQEKIK 170 SIKKKLSLLC 180 IDFNKNLNED 190 TTFLPFTREE 200 LGGLPEDFLN 210 SLEKTEDEKL 220 KVTLKYPHYF 230 PLLKKCHVPE 240 TRRKVEEAFN 250 CRCKEENCAI 260 LRELVRLRAQ 270 KSSLLGFSTH 280 ADYVLEMNMA 290 KTSQVVATFL 300 DELAQKLKPL 310 GEQERAVILE 320 LKKAECTKRG 330 LDFDGRINAW 340 DMRYYMNQVE 350 ETRYRVDQNL 360 LKEYFPMQVV 370 TRGLLGIYQE 380 LLGLTFHLEE 390 GAAVWHEDVM 400 LYSVRDAASG 410 KVIGKFYLDL 420 YPREGKYGHA 430 ACFGLQPGCL 440 RQDGSRQIAI 450 AAMVANFTKP 460 TPDAPSLLQH 470 DEVETYFHEF 480 GHVMHQLCSQ 490 AEFAMFSGTH 500 VERDFVEAPS 510 QMLENWVWEA 520 EPLLRMSQHY 530 RTGSAIPQEL 540 LEKLIKSRQA 550 NTGLFNLRQI 560 VLAKVDQALH 570 TQTAADPAEE 580 YARLCQEILG 590 VPATPGGHGL 600 QKLYPETWRL 610 RGCQRHVEAL 620 PGSGSQAGCL PPEQRTAG

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0004222	metalloendopeptidase activity
Biological Process	GO:0006508	proteolysis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.