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Overview

Uniprot IDA0A287AV47
Protein NameSerine/arginine repetitive matrix protein 1
Gene NameSRRM1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
86 KFAECLEKKVDMSKV

Function

Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates

Protein Sequence

10 MGAHSGALCQ 20 LCSPLSQDTR 30 SLHRKFPGKE 40 ANYCGSVSDE 50 STVQACRALP 60 AHIWEKQGTS 70 AEQDNRFSNK 80 QKKLLKQLKF 90 AECLEKKVDM 100 SKVNLEVIKP 110 WITKRVTEIL 120 GFEDDVVIEF 130 IFNQLEVKNP 140 DSKMMQINLT 150 GFLNGKNARE 160 FMGELWPLLL 170 SAQENIAGIP 180 SAFLELKKEE 190 IKQRQIEQEK 200 LASMKKQDED 210 KDKRDKEEKE 220 SSREKRERSR 230 SPRRRKSRSP 240 SPRRRSSPVR 250 RERKRSHSRS 260 PRHRTKSRSP 270 SPAPEKKEKT 280 PELPEPSVKV 290 KEPSVQEATS 300 TSDILKVPKP 310 EPVPEPKEPS 320 PEKNSKKEKE 330 KEKTRPRSRS 340 RSKSRSRTRS 350 RSPSHTRPRR 360 RHRSRSRSYS 370 PRRRPSPRRR 380 PSPRRRTPPR 390 RMPPPPRHRR 400 SRSPVRRRRR 410 SSASLSGSSS 420 SSSSSRSRSP 430 PKKAPKRTSS 440 PPRKTRRLSP 450 SASPPRRRHR 460 PSPPATPPPK 470 TRHSPTPQQS 480 NRTRKSRVSV 490 SPGRTSGKVT 500 KHKGTEKRES 510 PSPAPKPRKV 520 ELSESEEDKG 530 GKMAAADSVQ 540 QRRQYRRQNQ 550 QSSSDSGSSS 560 SSEDERPKRS 570 HVKNGEVGRR 580 RRHTPSRSAS 590 PSPRKRQKET 600 SPRMQMGKRW 610 QSPMTKSGRR 620 RRSPSPPPTR 630 RRRSPSPAPP 640 PRRRRSPTPP 650 PRRRTPSPPP 660 RRRSPSPRRY 670 SPPIQRRYSP 680 SPPPKRRTAS 690 PPPPPKRRAS 700 PSPPPKRRVS 710 HSPPPKQRSS 720 PVTKRRSPSL 730 SSKHRKGPSP 740 SRSTREARSP 750 QPNKRHSPSP 760 RPRAPQTCSS 770 PPPARRGASS 780 SPQRRQSPSP 790 SSRPIRRVSR 800 TPEPKKTKKV 810 ASPSPQSVRR 820 VSSSRSVSGS 830 PEPAAKKPPA 840 PPSPVQSQSP 850 STNWSPAVPV 860 KKAKSPTPSP 870 SPARNSDPEG 880 GGKKKKKKKD 890 KKHKKDKKHK 900 KHKKHKKEKA 910 VAAAAAAAVT 920 PTAIAAPTTT 930 SAQEEPEAEP 940 EPKKETESEA 950 EDNLDDLEKH 960 LREKALRSMR KAQVSPQS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0071013 catalytic step 2 spliceosome
Biological Process GO:0006397 mRNA processing
Biological Process GO:0048024 regulation of mRNA splicing, via spliceosome
Biological Process GO:0008380 RNA splicing
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005681 spliceosomal complex
Molecular Function GO:0003723 RNA binding

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.