Search Results

Overview

Uniprot IDA0A287AV71
Protein NameProtein 4.1
Gene NameEPB41L3
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
379 RAAKRLWKVCVEHHT
399 LPEAPPKKFLTLGSK

Function

Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase

Protein Sequence

10 MTTESGSDSE 20 SKPEQEAEPQ 30 EAAGPQGHAG 40 GQPGPEPGAE 50 EQPQAPEQFE 60 EAAAHSTPVR 70 KEVTDKEQEF 80 AAAAAKQLEY 90 QQFEDDKLSQ 100 KSSSSKLSRS 110 PLKIVKKPKS 120 MQCKVILLDG 130 SEYTCDVEKR 140 SRGQVLFDKV 150 CEHLNLLEKD 160 YFGLTYRDAE 170 NQKNWLDPAK 180 EIKKQIRSGA 190 WHFSFNVKFY 200 PPDPAQLSED 210 ITRYYLCLQL 220 RDDIVSGRLP 230 CSFVTLALLG 240 SYTVQSELGD 250 YDPDECGSDY 260 VSEFRFAPNH 270 TKELEDKVIE 280 LHKSHRGMTP 290 AEAEMHFLEN 300 AKKLSMYGVD 310 LHHAKDSEGV 320 DIMLGVCASG 330 LLIYRDRLRI 340 NRFAWPKVLK 350 ISYKRNNFYI 360 KIRPGEFEQF 370 ESTIGFKLPN 380 HRAAKRLWKV 390 CVEHHTFFRL 400 LLPEAPPKKF 410 LTLGSKFRYS 420 GRTQAQTRRA 430 SALIDRPAPY 440 FERSSSKRYT 450 MSRSLDGEVG 460 TGQYATTKGI 470 SQTNLITTVT 480 PEKKAEEERD 490 EEEERRKKAE 500 EATPVATVRH 510 EGKSPGLGTD 520 SCSLSPPSAH 530 RAPASPTELR 540 RRCKEKERPP 550 PGAEPSRDPG 560 HLCGEPTSDS 570 DGQGKPRLRD 580 QDVAFSYKQQ 590 AGRGATLFSF 600 SLQLPASFPS 610 LLDDDGYLSF 620 PSLSETSLLP 630 QSLQHYLPIR 640 SPSLVPCFLF 650 IFFFLLSASF 660 SVPYALTLSF 670 PLALCLCYLE 680 PKAASLSASL 690 DNDPSDSSEE 700 ETDSERTDTA 710 ADGETTATES 720 DQEEDAELKA 730 QELDKTQDDL 740 MKHQTNISEL 750 KRTFLETSTD 760 TAVTNEWEKR 770 LSTSPVRLAA 780 RPEEAPMIEP 790 LVPEETKQSS 800 GEKLMDGSEI 810 FSLLESARKP 820 TEFIGGVTST 830 SQSWVQKTET 840 KTESSETETE 850 TTQRPQPLST 860 ETVVQETVLV 870 EERHVMSVHA 880 SGDASSTAGD 890 GVDAAAQAAS 900 AEASGVKGKE 910 GSALTEGAKE 920 DKGEVADRAV 930 LEQEVMATAS 940 QEPEEERLSA 950 AIHVSETLEQ 960 KPHFESSTVK 970 TETISFGSVS 980 PGGIKLEIST 990 KEVPVVHTET 1000 KTITYESSQV 1010 DLGADLEPGV 1020 LMSAQTITSE 1030 TTSTTTTTHI 1040 TRTVKGGISE 1050 TRIEKRIVIT 1060 GDADIDHDQA 1070 LAQAIKEAKE 1080 QHPDMSVTKV 1090 VVHKETEITP EDGED

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0005856 cytoskeleton
Molecular Function GO:0003779 actin binding
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0030866 cortical actin cytoskeleton organization

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.