Search Results
Overview
| Uniprot ID | A0A287AVD8 |
|---|---|
| Protein Name | Integrin-linked kinase-associated serine/threonine phosphatase 2C |
| Gene Name | ILKAP |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 185 | GDVISVEKTVKRCLL |
| 250 | RYNEESQKHAALSLS |
| 299 | SIGDGQYKRCGVTSV |
| 373 | ACNRLATKAVQRGSA |
| 99 | LVEKKVCKASSAIFG |
Function
Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation
Protein Sequence
10
MDLFGDLPEP
20
ERSPRPAAGK
30
EAQKGSLLFD
40
GLPPASSADS
50
GSGGPLLFDD
60
LPPASSGDAG
70
SLDASPSQTG
80
KNEGKGAKRK
90
TSEEEKNGSE
100
ELVEKKVCKA
110
SSAIFGLKGY
120
VAERKGEREE
130
MQDAHVILND
140
ITEECRPPSS
150
LITRVSYFAV
160
FDGHGGIRAS
170
KFAAQNLHQN
180
LIRKFPKGDV
190
ISVEKTVKRC
200
LLDTFKHTDE
210
EFLKQASSQK
220
PAWKDGSTAT
230
CVLAVDNTLY
240
IANLGDSRAI
250
LCRYNEESQK
260
HAALSLSKEH
270
NPTQYEERMR
280
IQKAGGNVRD
290
GRVLGVLEVS
300
RSIGDGQYKR
310
CGVTSVPDIR
320
RCQLTPNDRF
330
ILLACDGLFK
340
VFTPEEAVHF
350
ILSCLEDEKI
360
QSREGKPAVD
370
ARYEAACNRL
380
ATKAVQRGSA
390
DNVTVMVVRI
GR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0016301 | kinase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0004722 | protein serine/threonine phosphatase activity |
| Biological Process | GO:0007229 | integrin-mediated signaling pathway |
| Biological Process | GO:0007165 | signal transduction |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.