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Overview

Uniprot IDA0A287AVR0
Protein NameEukaryotic translation initiation factor 3 subunit C
Gene NameEIF3C
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
114 AATFLKKKSEAPSGE
226 RGGVPLVKEKPKMFA
245 ITHAVVIKKLNEILQ
246 THAVVIKKLNEILQA
407 VQRYLEEKGTTEEIC
431 TYYKFDYKAHQRQLT
472 LCKYIYAKDRTDRIR
557 IQSSGRAKELLGQGL
578 ERNQEQEKVERRRQV
696 VRTMLVRKIQEESLR
791 NERVFDHKQGTYGGY
803 GGYFRDQKDGYRKNE

Function

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression

Protein Sequence

10 MSRFFTTGSD 20 SESESSLSGE 30 ELVTKPVGGN 40 YGKLWEDKEG 50 KKKMNKNNAK 60 ALSTLRQKIR 70 KYNRDFESHI 80 TNYKQNPEQS 90 ADEDAEKNEE 100 DSEGSSDEDE 110 DDDGVSAATF 120 LKKKSEAPSG 130 ESRKFLKKME 140 DEDEDSEDSE 150 DDEDWDTGST 160 SSDSDSEEEE 170 GKQTVLASRF 180 LKKAPTTEED 190 KKAAEKKRED 200 KAKKKHDRKS 210 KRLDEEEEDN 220 EGGEWERVRG 230 GVPLVKEKPK 240 MFAKGTEITH 250 AVVIKKLNEI 260 LQARGKKGTD 270 RAVQIEMLQL 280 LVQIASENNL 290 GEGVIVKIKF 300 NIIASLYDYN 310 PNLATYMKPE 320 MWQKCLDCIN 330 ELMDILFANP 340 NIFVGENILE 350 ESENLHNADQ 360 PLRVRGCILT 370 LVERMDEEFT 380 KIMQNTDPHS 390 QEYVEHLKDE 400 AQVCAIIERV 410 QRYLEEKGTT 420 EEICRIYLRR 430 ILHTYYKFDY 440 KAHQRQLTPP 450 EGSSKSEQDQ 460 AENEGEDSAV 470 LMERLCKYIY 480 AKDRTDRIRT 490 CAILCHIYHH 500 ALHSRWYQAR 510 DLMLMSHLQD 520 NIQHSDPPVQ 530 ILYNRTMVQL 540 GICAFRQGLT 550 KDAHNALLDI 560 QSSGRAKELL 570 GQGLLLRSLQ 580 ERNQEQEKVE 590 RRRQVPFHLH 600 INLELLECVY 610 LVSAMLLEIP 620 YMAAHESDAR 630 RRMISKQFHH 640 QLRVGERQPL 650 LGPPESMREH 660 VVAASKAMKM 670 GDWKTCHSFI 680 INEKMNGKVW 690 DLFPEADKVR 700 TMLVRKIQEE 710 SLRTYLFTYS 720 SVYDSISMET 730 LSDMFELDLP 740 TVHSIISKMI 750 INEELMASLD 760 QPTQTVVMHR 770 TEPTAQQNLA 780 LQLAEKLGSL 790 VENNERVFDH 800 KQGTYGGYFR 810 DQKDGYRKNE 820 GYMRRGGYRQ QQSQTAY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016282 eukaryotic 43S preinitiation complex
Cellular Component GO:0033290 eukaryotic 48S preinitiation complex
Cellular Component GO:0005852 eukaryotic translation initiation factor 3 complex
Cellular Component GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003743 translation initiation factor activity
Molecular Function GO:0031369 translation initiation factor binding
Biological Process GO:0001732 formation of cytoplasmic translation initiation complex
Biological Process GO:0006413 translational initiation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.