Search Results
Overview
| Uniprot ID | A0A287AWS9 |
|---|---|
| Protein Name | Heme oxygenase 1 |
| Gene Name | HMOX1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 47 | EFMKNFQKGEVTREG |
Function
Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis
Protein Sequence
10
PAHSHPLAHC
20
PPPLYSVPQD
30
LSEALKEATK
40
EVHVQAENAE
50
FMKNFQKGEV
60
TREGFKLVMA
70
SLYHIYDALE
80
EEIEHNKENP
90
VYTPLYFPEE
100
LHRRAALEQD
110
MAFWYGPRWQ
120
EAIPYTQATK
130
RYVRRLQQVG
140
RFEPELLVAH
150
VLKKIAQKAL
160
DLPSSGEGLA
170
FFTFPNVANA
180
TKFKQLYRSR
190
MNTLEMTPEV
200
KQRVLEEAKT
210
AFLLNIQLFE
220
EVQELLTQDT
230
KDQRPSQASD
240
VRKRAGSRVQ
250
DSTPVTTPRG
260
KPQLSVLSQV
270
PLVRWVLTLS
280
FLVATVAMGL
YAM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Molecular Function | GO:0004392 | heme oxygenase (decyclizing) activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0006788 | heme oxidation |
| Biological Process | GO:0043922 | host-mediated suppression of viral transcription |
| Biological Process | GO:1903901 | negative regulation of viral life cycle |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.