Search Results
Overview
| Uniprot ID | A0A287AWX3 |
|---|---|
| Protein Name | Farnesyl pyrophosphate synthase |
| Gene Name | RUSC1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 297 | YGQKDAEKVARVKAL |
| 46 | GDAVARLKEVLEYNV |
| 57 | EYNVVGGKYNRGITV |
| 76 | RELVEPRKQDADSLQ |
Function
Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate
Protein Sequence
10
MNGDQKLDAY
20
ARERQDFIQH
30
FSQIVKVLTE
40
EDIGHPEIGD
50
AVARLKEVLE
60
YNVVGGKYNR
70
GITVLVVFRE
80
LVEPRKQDAD
90
SLQRALTVGW
100
CIELLQAFFL
110
VADDIEDSSL
120
TRRGQTCWYR
130
KPGIGLDAIN
140
DAFLLEACIY
150
RLLKFYCREQ
160
PYYLNLIELF
170
LQTSYNTEIG
180
QTLDLIAGPQ
190
GNVDLSRFTE
200
KRYKSIVKYK
210
TAFYSFYLPV
220
AAAMYMAGID
230
GEKEHANAKK
240
ILMEMGEFFQ
250
IQDDYLDLFG
260
DPSVTGKIGT
270
DIQDNKCSWL
280
VVQCLQRASP
290
EQRQILQENY
300
GQKDAEKVAR
310
VKALYEEMNL
320
QAVFLQYEED
330
SYSHLMGLIE
340
QYAAPLPPAI
350
FLELAHKIYK
RRK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005777 | peroxisome |
| Molecular Function | GO:0004337 | (2E,6E)-farnesyl diphosphate synthase activity |
| Molecular Function | GO:0004161 | dimethylallyltranstransferase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0006695 | cholesterol biosynthetic process |
| Biological Process | GO:0045337 | farnesyl diphosphate biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.