Search Results
Overview
| Uniprot ID | A0A287AX55 |
|---|---|
| Protein Name | Sphingosine-1-phosphate lyase 1 |
| Gene Name | SGPL1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 398 | SVVLYSDKKYRNYQF |
| 454 | EATKQIIKTTRFLKA |
| 460 | IKTTRFLKAELENIK |
Function
Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP. Seems to play a role in establishing neuronal contact sites and axonal maintenance
Protein Sequence
10
MRGELGRRVG
20
VPTTRGLKGR
30
HRKEGWKRKM
40
PSTDLLMLKA
50
FEPYFEILEV
60
YSTKAKNYVN
70
GHCTKYEPWQ
80
LIAWSVVWTL
90
LIVWVYKFVF
100
QPESLWSRFK
110
KRCVKLIRKM
120
PVIGRKIQDK
130
LNKTKDDISK
140
NMSFLKVDKE
150
YVKALPSQGL
160
SPAAVLEKLK
170
EYSSLDVSWQ
180
EGKASGAVYS
190
GEKELTELLV
200
KAYGDFAWSN
210
PLHPDIFPGL
220
RKIEAEIVRM
230
ACSLFNGGPD
240
SCGCVTSGGT
250
ESILMACKAY
260
RELAFENGIK
270
TPEIVAPQSA
280
HAAFDKAANY
290
FGMKIIRVPL
300
NKMMEVDIRA
310
MRRAISRNTA
320
MLVCSTPQYP
330
HGVIDPVPEV
340
AKLAVKYKIP
350
LHVDACLGGF
360
LIVFMEKAGY
370
PLEQPFDFRV
380
KGVTSISADT
390
HKYGYAPKGS
400
SVVLYSDKKY
410
RNYQFFVATD
420
WQGGIYASPT
430
MAGSRPGGIS
440
AACWAALMYF
450
GENGYVEATK
460
QIIKTTRFLK
470
AELENIKGIF
480
VFGNPQLSVI
490
ALGSRDFDIF
500
RLFNLMTAKG
510
WNLNQLQFPP
520
SIHFCITLVH
530
TRKRVAIQFL
540
KDIRESVTQI
550
MKNPKAKTTG
560
MGAIYGMAQA
570
TIDRNLVAEL
580
SSFFLDSLFS
590
TDAVPQGSQM
NGSPKPR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Molecular Function | GO:0030170 | pyridoxal phosphate binding |
| Molecular Function | GO:0008117 | sphinganine-1-phosphate aldolase activity |
| Biological Process | GO:0019752 | carboxylic acid metabolic process |
| Biological Process | GO:0006665 | sphingolipid metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.