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Overview

Uniprot ID	A0A287AXQ5
Protein Name	Melanoma inhibitory activity protein 2
Gene Name	MIA2
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
862	VEQVLCDKENQIKSL

Function

Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum. Thereby, may play a role in cholesterol and triglyceride homeostasis. Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites

Protein Sequence

10 MAELGIHRIL 20 LLVISLTKCL 30 EGTKRLADFK 40 KCGDLECETL 50 ISRVLAIRDY 60 RGPDCRYLNF 70 TKGEEISVYI 80 KLAGEKEDLW 90 AGSKGKDFGY 100 FPRDAVQIEE 110 VFISEEVQIS 120 TKESDFFCLL 130 GISYTFENED 140 IELNIDHSDN 150 IYLYEEDEDP 160 KSNVYESDFQ 170 IEPGFFSTSE 180 GTLFEDQFPA 190 SEAPEAIRST 200 SESKDWEAAE 210 VRSVEEHPLP 220 EVDHVPPSSA 230 VPEVKGWFGF 240 RKDQAEGETF 250 ESVIEPLQES 260 SLLSRKIAVE 270 DENDPEKLNN 280 DEPQTEHKQE 290 PESEVDSMPT 300 KQSELVSESE 310 HYPQDTGWFG 320 GRFTSYFGFR 330 GEDTGLELLS 340 KESNPPLQDV 350 PNSISSEEES 360 TVPCTETLTE 370 KEDTLTNDSS 380 ILKPRWFEFG 390 FAMLGIAYAN 400 EDKIISDDGK 410 NEESGGEDKH 420 GPPPTSEFDP 430 GEEQELKIMK 440 IVETESQIGK 450 EGALEKTDDS 460 DTLPYFKKFL 470 GNFENSWNFK 480 NIPKETELPF 490 PKKTLDENNV 500 GENDETEEFS 510 LENYPTDNTE 520 DMTLESRYSQ 530 SDMNSKIELP 540 MIIHEEVHFK 550 TLSSENNDEN 560 SKTSLDTERS 570 TMVEIDTSVE 580 NTLPNSQIFS 590 TDYSLSSQNY 600 LDQKEDASVG 610 QILKYLFQID 620 VFDFLNPAFS 630 PIVILTGRVV 640 AALPEDMNFH 650 GFPWEVVICA 660 TIVGLFAVVL 670 FLWRSFRSVR 680 REKKLAAELS 690 ALIEEKCKLL 700 EKFSLVQKEY 710 EGLESSLKDA 720 SFEKESTEAQ 730 SLEEVVFLFQ 740 AFCGKLINSQ 750 SELEDEILFL 760 EKELREEKSK 770 HSEQDELMVD 780 ISKRIQSLED 790 ESKSLKSQVS 800 EAKTTFKIFQ 810 MNEERLKISI 820 KDALSENSQL 830 QESQKQLLQE 840 AEEWRERVNE 850 LNKQKMTFED 860 SRAHVEQVLC 870 DKENQIKSLT 880 ERLLKMKDWS 890 AVLGEDITND 900 DNLDLEMKND 910 SENDTLPKGT 920 LKKLIHAAKL 930 KASLKTLEGE 940 RNQIYTQLSE 950 VDKTKEDLTE 960 CIENLQTEQA 970 SLQSENTQFE 980 NEIQKLQQKL 990 KVMTELYQEN 1000 EMTLHRKLTV 1010 EENYRLEKEE 1020 KLSKADEKIS 1030 HAVEELETYR 1040 KRARDLEEEL 1050 ERTIHSYQGQ 1060 VCVCISLKTV 1070 LAARNAERNL 1080 NDLRKENAYS 1090 RQKLTETELK 1100 FELLEKDPYA 1110 LDVPNTAFGR 1120 EHSPYGPSPL 1130 GRPSPETRAF 1140 LSPPTLLEGP 1150 LRLSPLLPGG 1160 GGRGSRGPGN 1170 PLDHPITNER 1180 GDSSADWLID 1190 PHRAPSDTGS 1200 LSPPWEQDRR 1210 MMIPPSGQPY 1220 PDPVFPPQRQ 1230 DRFYSNSGRL 1240 SGPAELRSFN 1250 MPSLDKVDGP 1260 VSSEMESNRT 1270 DGKDDLGNLN 1280 VPDSSLPNES 1290 EATGPGFVPP 1300 PRPPVRGPLF 1310 PLDARGPFLR 1320 RGPPFPPPPP 1330 GSMYAAPRDY 1340 FPPRDFPGPP 1350 PPPFAMRSVY 1360 PPRGFPHYLP 1370 PRAGFFPPPP 1380 HPESRSEFPA 1390 GLIPPSNEPT 1400 TEHPEPQQET

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005789	endoplasmic reticulum membrane

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.