Search Results

Overview

Uniprot ID	A0A287AY04
Protein Name	Serine/threonine-protein kinase MRCK beta
Gene Name	CDC42BPB
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
1198	VRVADYKKVYQIELA

Function

Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A. In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation

Protein Sequence

10 MSAKVRLKKL 20 EQLLLDGPWR 30 NESALSVETL 40 LDVLVCLYTE 50 CSHSALRRDK 60 YVAEFLEWAK 70 PFTQLVKEMQ 80 LHREDFEIIK 90 VIGRGAFGEV 100 AVVRMKSTER 110 IYAMKILNKW 120 EMLKRAETAC 130 FREERDVLVN 140 GDSQWLTTLH 150 YAFQDENYLY 160 LVMDYYVGGD 170 LLTLLSKFED 180 RLPEDMARFY 190 IGEMVLAIDS 200 IHQLHYVHRD 210 IKPDNVLLDV 220 NGHIRLADFG 230 SCLKMNDDGT 240 VQSSVAVGTP 250 DYISPEILQA 260 MEDGMGRYGP 270 ECDWWSLGVC 280 MYEMLYGETP 290 FYAESLVETY 300 GKIMNHEEIL 310 PPASHTGFSG 320 LHLPFIGFTF 330 TTESCFSDRG 340 SLKSIMQSST 350 LTKDEGLQRD 360 LENSLQVEAY 370 ERRIRRLEQE 380 RLELSRKLQE 390 ATQTVQSFHG 400 AARTLGSAAR 410 DKEIKKLNEE 420 IERLKNKIAE 430 SNKLERQLED 440 TVTLRQEQED 450 STHRLKGLEK 460 QYRAVRQEKE 470 DFHKQLIEAS 480 ERLKSQAREL 490 KDAHQQRKLA 500 LQEFSELNER 510 MAELRSQKQK 520 VSRQLRDREE 530 EVEAALQKID 540 ALRQEVRRAD 550 KCRKELEAQL 560 EDAVAEASKE 570 RKLREHSENF 580 SKQIESELEA 590 LKMKQGGRGP 600 GAALEHQQEI 610 SRIKSELEKK 620 VLFYEEELVR 630 REASHVLELK 640 TVKKEVHDSE 650 GHQLALQKEV 660 LVLKDKLEKS 670 KRERHSELEE 680 AVGTVKDKYE 690 RERAVLSEEN 700 KKLTAENEKL 710 CAFVDKLTAQ 720 NRQLEDELQD 730 LAAKKESVAH 740 WEAQIAEIIQ 750 WVSDEKDARG 760 YLQALASKMT 770 EELEALRSSS 780 LGSRTLDPLW 790 KVRRSQKLDM 800 SARLELQSAL 810 EAEIRAKQLV 820 QEELRKVKDM 830 NLSFESKLKD 840 SEAKNRELLE 850 EMEILKKKME 860 EKFRTDAGLK 870 LPDFQDSIFE 880 YFNTAPLAHD 890 LTFRASSASE 900 QETQAAKPEA 910 MPPSSVAAST 920 EQQEDVARAP 930 QRPPTVPLPS 940 TQALALAGPK 950 PKAHQFSIKS 960 FSSPTQCSHC 970 TSLMVGLIRQ 980 GYACDVCSFA 990 CHVSCRDSAP 1000 QVCPIPPEQS 1010 KRPLGVDVQR 1020 GIGTAYKGYV 1030 KVPKPTGVKK 1040 GWQRAYAVVC 1050 DCKLFLYDLP 1060 EGKSTQPGVV 1070 ASQVLDLRDE 1080 EFSVSSVLAS 1090 DVIHASRRDI 1100 PCIFRVTASL 1110 LGTPSKTSSL 1120 LILTENENEK 1130 RKWVGILEGL 1140 QSILQKNRLR 1150 SQVVHSPQEA 1160 YDSSLPLIKA 1170 VLAAAILDAD 1180 RIAVGLEEGL 1190 YVVEVTRDVI 1200 VRVADYKKVY 1210 QIELAPKEKV 1220 AALLCGRNHH 1230 VHLCPWSSFD 1240 GAEGTVDIKL 1250 PETKGCQLIA 1260 TGAPKKSSPT 1270 CLFVAVKRLV 1280 LCYEMQRTKP 1290 FHRKLSELAA 1300 PGPVQWMAVL 1310 KDKLCVGYPS 1320 GFSLLSPQGE 1330 GQALNLVNPN 1340 DPSLTFLSQQ 1350 SFDALCAVEL 1360 QSEEYLLCFS 1370 HMGLYVDPQG 1380 RRSRMQELMW 1390 PAAPVACSCS 1400 PSHVTVYSDY 1410 GVDVFDARSM 1420 EWVQTIGLRR 1430 IRPLNSEGSL 1440 NLLNCEPPRL 1450 IYFKSKFAGP 1460 ALNVPDTSDN 1470 SKKQMLRTRS 1480 KRRFVFKVPE 1490 EERLQQRREM 1500 LRDPELRSRM 1510 ISNPTNFNHV 1520 AHMGPGDGMQ 1530 VLMDLPLSAV 1540 PPSQEERPGP 1550 APASLSRQPP 1560 PRNKPYVSWP 1570 SSGGSEPGVA 1580 VPLRSMSDPD 1590 QDFDKEPDSD 1600 STKHSTPSNS 1610 SNPSGPPSPN 1620 SPHRSQLPLE GLEQPSYDA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0042641	actomyosin
Cellular Component	GO:0070161	anchoring junction
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0030027	lamellipodium
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0004674	protein serine/threonine kinase activity
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0031032	actomyosin structure organization
Biological Process	GO:0016477	cell migration

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.