Search Results

Overview

Uniprot ID	A0A287AYC6
Protein Name	-
Gene Name	LOC100626015
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
547	VNRFCLSKPGVYKVT
552	LSKPGVYKVTPRSCH

Function

Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions

Protein Sequence

10 MSRRSGWEGD 20 FSLHTSLEPT 30 TVELYVDGVS 40 DICTKGGDIN 50 FVFTGFSVNG 60 KVLSKGQPLG 70 PAGVQVSLRS 80 TGTDAKIQST 90 VTQPGGKFAF 100 FKVLPGDYEI 110 LATHPTWALK 120 EASTTVRVTN 130 SNANAAGPLI 140 VAGYNVSGSV 150 RSDGEPMKGV 160 KFLLFSSSVS 170 KEDVLGCNIS 180 PVPGFQPQDE 190 SLVYLCHVVS 200 KEDGSFSFYS 210 LPNGGYTVIP 220 FYRGERITFD 230 VAPSRLDFTV 240 EHDSLKIEPV 250 FHVMGFSVTG 260 RVLNGPEGEG 270 VPDAVVTLNN 280 QIKVRTKADG 290 SFRLENITTG 300 TYTIHAQKEH 310 LYFETVTIKI 320 APNTPQLADI 330 IATGFSVCGQ 340 ISILRFPDTV 350 KQMSKYKVVL 360 SSQDKDKSLV 370 TVETDAQGSF 380 CFKAKPGTYK 390 VQVMVPEVET 400 RAGLTLKPQT 410 LLLAVTDRPV 420 MDVAFVQFLA 430 SVSGKVSCLD 440 TCGDLLVTLQ 450 SLSRQGEKRS 460 LQLSGKLNSM 470 TFTFDNVLPG 480 KYKTSIMHED 490 WCWKNKSLEV 500 EVLEEDVSAV 510 EFRQTGYMLR 520 CSLSHAITLE 530 FYQDGNGPEN 540 VGIYNLSKGV 550 NRFCLSKPGV 560 YKVTPRSCHR 570 FEQAFYTYDT 580 SSPSILTLTA 590 IRHHVLGTIT 600 TDKMMDVTVT 610 IKSSIDSEPA 620 LVLGPLKSVQ 630 ELRREQQLAE 640 IESRRQEREK 650 NGGEEGGEGG 660 TKPPVQEMVD 670 ELQGPFSYDF 680 SYWARSGEKI 690 TVTPSSKELL 700 FYPPSMEATV 710 SGESCPGKLI 720 EIQGKAGLFL 730 EGQIHPELEG 740 VEIVISEKGA 750 SSPLITVFTD 760 DKGAYSVGPL 770 HSDLEYTVSS 780 QKEGYVLTAV 790 EGTIGDFKAY 800 ALAGVSFEIK 810 AEDDQPLPGV 820 LLSLSGGVFR 830 SNLLTQDNGI 840 LTFSNLSPGQ 850 YYFKPMMKEF 860 RFEPSSQMIE 870 VQEGQNLKIT 880 ITGYRTAYSC 890 YGTVSSLNGE 900 PEQGVAVEAV 910 GQNDCSIYGE 920 DTVTDEEGKF 930 RLRGLLPGCV 940 YHVQLKAEGN 950 DHIERALPHH 960 RVITVGNNDI 970 DDVNIIVFRQ 980 INQFDLSGNV 990 ITSSEYLPTL 1000 WVKLYKSDNL 1010 DNPIQTVSLG 1020 QSLFFHFPPL 1030 LRDGQNYVVL 1040 LDSTLPKSQY 1050 DYVLPQVTFT 1060 AAGYHKHITL 1070 IFNPARKLPE 1080 QDIAQGSYIA 1090 LPLTLLVLLA 1100 GYNHDKLIPL 1110 LLQLTSRLQG 1120 VRALGQTASD 1130 GSGPEDAKRQ AKKQKTRRT

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0160064	multi-pass translocon complex
Molecular Function	GO:0030246	carbohydrate binding
Molecular Function	GO:0043022	ribosome binding
Biological Process	GO:0160063	multi-pass transmembrane protein insertion into ER membrane

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.