Search Results
Overview
| Uniprot ID | A0A287AZ25 |
|---|---|
| Protein Name | Splicing factor 1 |
| Gene Name | PYGM |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 15 | TPLDFPSKKRKRSRW |
| 165 | GPRGNTLKNIEKECN |
| 169 | NTLKNIEKECNAKIM |
| 174 | IEKECNAKIMIRGKG |
| 281 | TNTTVCTKCGGAGHI |
| 306 | DPQSAQDKARMDKEY |
Function
Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor
Protein Sequence
10
MATGANATPL
20
DFPSKKRKRS
30
RWNQDTMEQK
40
TVIPGMPTVI
50
PPGLTREQER
60
AYIVQLQIED
70
LTRKLRTGDL
80
GIPPNPEDRS
90
PSPEPIYNSE
100
GKRLNTREFR
110
TRKKLEEERH
120
NLITEMVALN
130
PDFKPPADYK
140
PPATRVSDKV
150
MIPQDEYPEI
160
NFVGLLIGPR
170
GNTLKNIEKE
180
CNAKIMIRGK
190
GSVKEGKVGR
200
KDGQMLPGED
210
EPLHALVTAN
220
TMENVKKAVE
230
QIRNILKQGI
240
ETPEDQNDLR
250
KMQLRELARL
260
NGTLREDDNR
270
ILRPWQSSET
280
RSITNTTVCT
290
KCGGAGHIAS
300
DCKFQRPGDP
310
QSAQDKARMD
320
KEYLSLMAEL
330
GEAPVPASVG
340
STSGPASTPL
350
ASAPRPAAPA
360
NNPPPPSLMS
370
TTQSRPPWMN
380
SGPSESRPYH
390
GMHGGGPGGP
400
GGGPHSFPHP
410
LPSLTGGHGG
420
HPMQHNPNGP
430
PPPWMQPPPP
440
PMNQGPHPPG
450
HHGPPPMDQY
460
LGSTPVGSGV
470
YRLHQGKGMM
480
PPPPMGMMPP
490
PPPPPSGQPP
500
PPPSGPLPPW
510
QQQQQQPPPP
520
PPPSSSMASS
530
TPLPWQQNTT
540
TTTTSAGTGS
550
IPPWQQQQAA
560
AAASPGAPQM
570
QGNPTMVPLP
580
PGVQPPLPPG
590
APPPPPPPPP
600
GSAGMMYAPP
610
PPPPPPMDPS
620
NFVTMMGMGV
630
AGMPPFGMPP
APPPPPPQN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005681 | spliceosomal complex |
| Molecular Function | GO:0045131 | pre-mRNA branch point binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0000398 | mRNA splicing, via spliceosome |
| Biological Process | GO:0080090 | regulation of primary metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.