Search Results
Overview
| Uniprot ID | A0A287AZ57 |
|---|---|
| Protein Name | Nuclear pore glycoprotein p62 |
| Gene Name | NUP62 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 460 | RKVEEVTKVCEGRRK |
Function
Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex. Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation. It might be involved in protein recruitment to the centrosome after nuclear breakdown
Protein Sequence
10
MSRFNFGGTG
20
APTGGFTFGA
30
AKTATTTPAA
40
FSFSTSGTGG
50
FNFGTPSQPA
60
SSTPSTSLFS
70
LTTQASATAQ
80
APGFSFGTTT
90
PAAGGTGFSL
100
GLSTPKLNLS
110
SSAAATPAPA
120
QPSGFGLGGS
130
TLSNAVSSAV
140
TSAQGSTPSG
150
FVFGSTTTSA
160
APSTTPGGFS
170
FTSGSTSQTG
180
TSSFNIGSVG
190
SSAQPTALPG
200
LPFTPATPVA
210
TGAGATQPAA
220
PTPTTPPPPP
230
LKPPGAASTT
240
SAATTTTAAT
250
ATTTGLALNL
260
KPLAPAAIPS
270
NTAASGTAAA
280
GPSAATGVSA
290
NPAMTYAQLE
300
SLINKWSLEL
310
EDQERHFLQQ
320
ATQVNAWDRT
330
LIENGEKITT
340
LHREVEKVKL
350
DQKRLDQELD
360
FILSQQKELE
370
DLLSPLEESV
380
KEQSGTVYLQ
390
HADEEREKTY
400
KLAENIDAQL
410
KRMAQDLKDI
420
IEHLNTSGGP
430
ADTSDPLQQI
440
CKILNAHMDS
450
LQWIDQNSAL
460
LQRKVEEVTK
470
VCEGRRKEQE
RSLRITFD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0090543 | Flemming body |
| Cellular Component | GO:0072686 | mitotic spindle |
| Cellular Component | GO:0031965 | nuclear membrane |
| Cellular Component | GO:0044613 | nuclear pore central transport channel |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Cellular Component | GO:0000922 | spindle pole |
| Molecular Function | GO:0030544 | Hsp70 protein binding |
| Molecular Function | GO:0051879 | Hsp90 protein binding |
| Molecular Function | GO:0005543 | phospholipid binding |
| Molecular Function | GO:0051425 | PTB domain binding |
| Molecular Function | GO:0042169 | SH2 domain binding |
| Molecular Function | GO:0030159 | signaling receptor complex adaptor activity |
| Molecular Function | GO:0017056 | structural constituent of nuclear pore |
| Molecular Function | GO:0043130 | ubiquitin binding |
| Biological Process | GO:0007166 | cell surface receptor signaling pathway |
| Biological Process | GO:0098534 | centriole assembly |
| Biological Process | GO:0007100 | mitotic centrosome separation |
| Biological Process | GO:0007080 | mitotic metaphase chromosome alignment |
| Biological Process | GO:0051028 | mRNA transport |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway |
| Biological Process | GO:0046580 | negative regulation of Ras protein signal transduction |
| Biological Process | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0046601 | positive regulation of centriole replication |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:1903438 | positive regulation of mitotic cytokinetic process |
| Biological Process | GO:0045840 | positive regulation of mitotic nuclear division |
| Biological Process | GO:1904781 | positive regulation of protein localization to centrosome |
| Biological Process | GO:0006606 | protein import into nucleus |
| Biological Process | GO:0060236 | regulation of mitotic spindle organization |
| Biological Process | GO:0006405 | RNA export from nucleus |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.