Search Results
Overview
| Uniprot ID | A0A287B044 |
|---|---|
| Protein Name | Filamin-binding LIM protein 1 |
| Gene Name | FBLIM1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 274 | CYQDTLEKCGKCGEG |
| 277 | DTLEKCGKCGEGVRE |
| 330 | CLDDFYRKFAPVCSI |
| 393 | LNNRLFCKPCHVKRS |
| 87 | RESPVPVKAPGAGSA |
Function
Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion
Protein Sequence
10
MTFGAPSVAG
20
WVAAPPHPEP
30
CPRLSPTLSP
40
APPGAKAMAS
50
KPEKRVASSV
60
FITLAPPRRD
70
EAVVEEVKRA
80
ACEARPGCPR
90
ESPVPVKAPG
100
AGSAGRLRSW
110
APPGRASAPV
120
PAVPPQLSNG
130
GCSLPPPPLD
140
GEDSLPDLDL
150
LPPPPPPPPP
160
MYLPPPDQEP
170
PASVGALVSD
180
LEQLHLPPPP
190
PPPQVWPPLG
200
QWSPLSQGRE
210
GLASHSLCLS
220
TPDICAFCHK
230
TVSPRELAVE
240
AMKRQYHAQC
250
FTCRVCRRQL
260
AGQSFYQKDG
270
RPLCEPCYQD
280
TLEKCGKCGE
290
GVREHIIRAL
300
GQAFHPTCFT
310
CVTCARCIGD
320
ESFALDSQNE
330
VYCLDDFYRK
340
FAPVCSICEN
350
PIIPRDGKDA
360
FKIECMGRNF
370
HENCYRCEDC
380
RILLSVEPTD
390
QGCYPLNNRL
400
FCKPCHVKRS
AASCC
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0001725 | stress fiber |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0008360 | regulation of cell shape |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.