Search Results
Overview
| Uniprot ID | A0A287B186 |
|---|---|
| Protein Name | - |
| Gene Name | VAPB |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 131 | ELPAENDKPHDVEIN |
| 147 | IISTTASKTETPVVS |
| 167 | ALDDTEVKKVMEECK |
| 17 | LEPQHELKFRGPFTD |
| 174 | KKVMEECKRLQSEVQ |
| 43 | TDRNVCFKVKTTAPR |
Function
Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44. Interacts with STARD3 in a FFAT motif phosphorylation dependent manner. Via interaction with WDR44 participates in neosynthesized protein export. Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation
Protein Sequence
10
MAKVEQVLSL
20
EPQHELKFRG
30
PFTDVVTTNL
40
KLGNPTDRNV
50
CFKVKTTAPR
60
RYCVRPNSGI
70
IDAGASINVS
80
VMLQPFDYDP
90
NEKSKHKFMV
100
QSMFAPADTS
110
DMEAAWKEAK
120
PEDLMDSKLR
130
CVFELPAEND
140
KPHDVEINKI
150
ISTTASKTET
160
PVVSKALSSA
170
LDDTEVKKVM
180
EECKRLQSEV
190
QRLREENKQL
200
KEEDGLRMRK
210
PVPSNSPAPA
220
PATPGKEEGL
230
STRLLALVVL
240
FFIVGVIIGK
IAL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0048487 | beta-tubulin binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0033149 | FFAT motif binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0043495 | protein-membrane adaptor activity |
| Biological Process | GO:0030301 | cholesterol transport |
| Biological Process | GO:0090114 | COPII-coated vesicle budding |
| Biological Process | GO:0090158 | endoplasmic reticulum membrane organization |
| Biological Process | GO:0061817 | endoplasmic reticulum-plasma membrane tethering |
| Biological Process | GO:0006874 | intracellular calcium ion homeostasis |
| Biological Process | GO:0036498 | IRE1-mediated unfolded protein response |
| Biological Process | GO:0045070 | positive regulation of viral genome replication |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.