Overview
| Uniprot ID | A0A287B194 |
|---|
| Protein Name | Sorting nexin-2 |
|---|
| Gene Name | SNX2 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 183 |
SKSEFSVKRRFSDFL |
| 199 |
LHSKLASKYLHVGYI |
| 236 |
SSTEFVEKRRAALER |
| 367 |
IRLIAAVKGVFDHRM |
| 436 |
RDFEQISKTIRKEVG |
Function
Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Required for retrograde endosome-to-TGN transport of TGN38. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN
Protein Sequence
10
MAAEREPPPL
20
GDGKPTDFEE
30
LEDGEDLFTS
40
TVSTLESSPS
50
SPEPAAASLL
60
AEDIGTNSNG
70
PKPAEVVLDD
80
DREDLFAEAT
90
EEVSLDSPER
100
EPILSSEPSP
110
AVTPVTPTTL
120
IAPRIESKSM
130
SAPVIFDRSR
140
EEIEEEANGD
150
VFDIEIGVSD
160
PEKVGDGMNA
170
YMAYRVTTKT
180
SLSMFSKSEF
190
SVKRRFSDFL
200
GLHSKLASKY
210
LHVGYIVPPA
220
PEKSIVGMTK
230
VKVGKEDSSS
240
TEFVEKRRAA
250
LERYLQRTVK
260
HPTLLQDPDL
270
RQFLESSELP
280
RAVNTQALSG
290
AGILRMVNKA
300
ADAVNKMTIK
310
MNESDAWFEE
320
KQQQFENLDQ
330
QLRKLHASVE
340
ALVCHRKELS
350
ANTAAFAKSA
360
AMLELLSDYI
370
RLIAAVKGVF
380
DHRMKCWQKW
390
EDAQMTLLKK
400
RETEAKMMVA
410
NKPDKIQQAK
420
NEIREEIEEW
430
EAKVQQGERD
440
FEQISKTIRK
450
EVGRFEAKRV
460
KDFKTVIIKY
470
LESLVQTQQQ
480
LIKYWEAFLP
EAKAIA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0031901 |
early endosome membrane |
| Cellular Component |
GO:0030027 |
lamellipodium |
| Cellular Component |
GO:0030904 |
retromer complex |
| Molecular Function |
GO:0035091 |
phosphatidylinositol binding |
| Biological Process |
GO:0006886 |
intracellular protein transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.