Overview
| Uniprot ID | A0A287B1A2 |
|---|
| Protein Name | U3 small nucleolar RNA-associated protein 4 homolog |
|---|
| Gene Name | UTP4 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 70 |
TEALCWAKGQRLFSA |
Function
Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted d Involved in SSU pre-rRNA processing at sites A', A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase. May be a transcriptional regulator
Protein Sequence
10
MGEFKVHRVR
20
FFNYVPSGIR
30
CVAYNNQSNR
40
LAVSRTDGTV
50
EIYNLSANYF
60
QEKFFPGHES
70
RATEALCWAK
80
GQRLFSAGLN
90
GEIIEYDLQA
100
LNVKYAVDAF
110
GGPIWSMAAS
120
PSGSQLLVGC
130
EDGSVKLFQI
140
TPDKIQFERN
150
FDRQKSRILS
160
LSWHPSGTHI
170
AAGSIDYISV
180
FDVKSGSAIH
190
KMLVDRQYMG
200
VSKRKCIIWG
210
VAFLSDGTVI
220
SVDSAGKVQF
230
WDSATGTLVK
240
NHLIANADVQ
250
SIAISDQEDS
260
FVVGTAEGTV
270
FHFQLVSVTS
280
SSSEKQWVRT
290
KPFQHHTHDV
300
RAVAHSPTAL
310
ISGGTDTHLV
320
IRPLMEKVEV
330
KNYDAALRKI
340
TFPHRRLVFC
350
AKKKQLLLFQ
360
FAHHLELWRL
370
GSTVATGKHG
380
DTLPLSKNAD
390
HLLHLKTKGP
400
ENIICSCISP
410
CGSWVAYSTA
420
SRFFLYRLNY
430
DHDSVSLQRV
440
SKMPAFLRSA
450
LHILFSEDSS
460
KLFVASSQGS
470
LHIIRLLEGS
480
FKHLHTFQPQ
490
SGTVESMCLL
500
AVSPDGNWLA
510
ASGTSAGVHV
520
YNVKHLKLHC
530
TVPAYNFPVT
540
ALAIAPKTNN
550
LVIAHSDQQV
560
FEYSIPDKQY
570
TEWSRTIQKQ
580
GFHHLWLQRD
590
TPITHISFHP
600
KRPMHILLHD
610
AYMFCIIDKS
620
LPLLFMDLLD
630
EKTLVAVERP
640
LDDIIAQLPP
PIKKKKFGT
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030686 |
90S preribosome |
| Cellular Component |
GO:0005694 |
chromosome |
| Cellular Component |
GO:0005730 |
nucleolus |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0000462 |
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.