Overview
| Uniprot ID | A0A287B1B1 |
|---|
| Protein Name | Protein transport protein Sec61 subunit gamma |
|---|
| Gene Name | SEC61G |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 16 |
EPSRQFVKDSIRLVK |
Function
Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex. The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER
Protein Sequence
10
MDQVMQFVEP
20
SRQFVKDSIR
30
LVKRCTKPDR
40
KEFQKIAMAT
50
AIGFAIMGFI
60
GFFVKLIHIP
INNIIVGG
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005784 |
Sec61 translocon complex |
| Cellular Component |
GO:0071261 |
Ssh1 translocon complex |
| Molecular Function |
GO:0008320 |
protein transmembrane transporter activity |
| Molecular Function |
GO:0043022 |
ribosome binding |
| Biological Process |
GO:0031204 |
post-translational protein targeting to membrane, translocation |
| Biological Process |
GO:0006616 |
SRP-dependent cotranslational protein targeting to membrane, translocation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.