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Overview

Uniprot IDA0A287B1K5
Protein NameEndoplasmic reticulum transmembrane helix translocase
Gene NameATP13A1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
728 CPLKADSKAVIREIQ

Function

Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum. Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane. Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains

Protein Sequence

10 MAAAVGNAVP 20 CGARHCGARP 30 AGQPKPKPQP 40 RTVLAAGPAL 50 IASGDELVAA 60 VWPYRRLALL 70 RRLTVLPFAG 80 LLYPAWLGAA 90 AAGCWGWGSS 100 WAQIPEAALL 110 VLATICLAHA 120 LTVLSGHWSV 130 HAHCALTCTP 140 EYDPSKATFV 150 KVVPTPNNGS 160 TELVALHRDE 170 GEDGQEVLSF 180 EFQKIKYSYD 190 ALEKKRFLPV 200 AFPVGNAFSY 210 YQSNRGFQED 220 SEIRAAEKKF 230 GSNKAEMVVP 240 DFSELFKERA 250 TAPFFVFQVF 260 CVGLWCLDEY 270 WYYSVFTLSM 280 LVAFEASLVQ 290 QQMRNMSEIR 300 KMGNKPHMIQ 310 VYRSRKWRPI 320 ASDEVVPGDI 330 VSIGRSPQEN 340 LVPCDVLLLR 350 GRCIVDEAML 360 TGESVPQMKE 370 PIEDLSPNRV 380 LDLQADSRLH 390 VIFGGTKVVQ 400 HIPPQKATTG 410 LKPVDNGCVA 420 FVLRTGFNTS 430 QGKLLRTILF 440 GVKRVTANNL 450 ETFIFILFLL 460 VFAIAAAAYV 470 WIEGTKDPSR 480 NRYKLFLECT 490 LILTSVVPPE 500 LPIELSLAVN 510 TSLIALAKLY 520 MYCTEPFRIP 530 FAGKVEVCCF 540 DKTGTLTSDS 550 LVVRGVAGLR 560 DGKEVTPVSN 570 IPIETHRALA 580 SCHSLMQLDD 590 GTLVGDPLEK 600 AMLTAVDWTL 610 TKDEKVFPRS 620 IKTQGLKIHQ 630 RFHFASALKR 640 MSVLASYEKL 650 GSTDLCYIAA 660 VKGAPETLHS 670 MFAQCPPDYH 680 HIHTEISREG 690 ARVLALGYKE 700 LGHLTHQQAR 710 EVKREALECN 720 LKFVGFIVVS 730 CPLKADSKAV 740 IREIQNASHR 750 VVMITGDNPL 760 TACHVAQELH 770 FIEKAHTLIL 780 QPPTEKGQPC 790 EWRSIDGSII 800 LPLAPGSPKA 810 LALEHALCLT 820 GDGLAHLQAE 830 DPQLLLRLIP 840 YVQVFARVAP 850 KQKEFVITSL 860 KELGYVTLMC 870 GDGTNDVGAL 880 KHADVGEPLS 890 LGSGDCQHQL 900 GIRDTSPSKF 910 CVALLANAPE 920 RVIERRRRPR 930 DSPILSNSGV 940 RTTSRAAKQR 950 SGLPPPEEQL 960 ASQRDRLSQV 970 LRDLEDESTP 980 IVKLGDASIA 990 APFTSKLSSI 1000 QCICHVIKQG 1010 RCTLVTTLQM 1020 FKILALNALI 1030 LAYSQSVLYL 1040 EGVKFSDFQA 1050 TLQGLLLAGC 1060 FLFISRSKPL 1070 KTLSRERPLP 1080 NIFNLYTILT 1090 VMLQFCVHFV 1100 SLVYLYSEAQ 1110 ARSPEKQEQF 1120 VDLYKEFEPS 1130 LVNSTVYIMA 1140 MAMQMATFAI 1150 NYKGPPFMES 1160 LPENRPLVWS 1170 LAVSLFAIVG 1180 LLLGSSPDFN 1190 SQFGLVDIPV 1200 EFKLVIAQVL 1210 LLDFCLALLA 1220 DRVLQFFLGT PKLKVPS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0140358 P-type transmembrane transporter activity
Biological Process GO:0015031 protein transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.