Search Results

Overview

Uniprot IDA0A287B1U9
Protein NameNAD(P) transhydrogenase, mitochondrial
Gene NameNNT
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1097 MLLGDAKKTCDALQA
1105 TCDALQAKVRESYQK
350 TALIPGKKAPVLFNK
477 IPQGAPVKQKTVAEL
96 KEIFQNEKRVALSPA

Function

The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland

Protein Sequence

10 MLLASLSFLT 20 YLQGNWAFGK 30 LGAPRNMANL 40 LKTVVTGCSC 50 PFRSSWGSCK 60 VLPGKKDFLR 70 TFHTHQALWC 80 KAPVKPGIPY 90 KQLTVGVPKE 100 IFQNEKRVAL 110 SPAGVQALVK 120 QGFNVVVESG 130 AGEASKFSDD 140 HYRAAGAQIQ 150 GVKEVLASDL 160 VVKVRAPMLN 170 PTLGVHEADL 180 LKTSATLISF 190 IYPAQNPDLL 200 NKLSKRKTTV 210 LAMDQVPRVT 220 IAQGYDALSS 230 MANIAGYKAV 240 VLAANHFGRF 250 FTGQITAAGK 260 VPPAKILIVG 270 GGVAGLASAG 280 AAKSMGAIVR 290 GFDTRAAALE 300 QFKSLGAEPL 310 EVDLKESGEG 320 QGGYAKEMSK 330 EFIEAEMKLF 340 AQQCKEVDIL 350 ISTALIPGKK 360 APVLFNKEMI 370 ESMKEGSVVV 380 DLAAEAGGNF 390 ETTKPGELYV 400 HKGVTHIGYT 410 DLPSRMATQA 420 STLYSNNITK 430 LLKAISPDKD 440 NFYFEVKDDF 450 DFGTMGHVIR 460 GTVVMKDGEV 470 IFPAPTPKNI 480 PQGAPVKQKT 490 VAELEAEKAA 500 TITPFRKTMT 510 SASVYTAGLT 520 GILGLGLAAP 530 NLAFSQMVTT 540 FGLAGIVGYH 550 TVWGVTPALH 560 SPLMSVTNAI 570 SGLTAVGGLV 580 LMGGHLYPST 590 TSQGLAALAT 600 FISSVNIAGG 610 FLVTQRMLDM 620 FKRPTDPPEY 630 NYLYLLPAGT 640 FVGGYLAALY 650 SGYNIEQIMY 660 LGSGLCCVGA 670 LAGLSTQGTA 680 RLGNALGMIG 690 VAGGLAATLG 700 GLKPCPELLA 710 QMSGAMALGG 720 TIGLTIAKRI 730 QISDLPQLVA 740 AFHSLVGLAA 750 VLTCIAEYIV 760 EYPHFATDAA 770 ANLTKIVAYL 780 GTYIGGVTFS 790 GSLIAYGKLQ 800 GILKSAPLLL 810 PGRHLLNAGL 820 LAASVGGIIP 830 FMVDPSFTTG 840 ITCLGSVSAL 850 SAVMGVTLTA 860 AIGGADMPVV 870 ITVLNSYSGW 880 ALCAEGFLLN 890 NNLLTIVGAL 900 IGSSGAILSY 910 IMCVAMNRSL 920 ANVILGGYGT 930 TSTAGGKPME 940 ISGTHTEINL 950 DNAIDMIREA 960 NSIIITPGYG 970 LCAAKAQYPI 980 ADLVKMLSEQ 990 GKKVRFGIHP 1000 VAGRMPGQLN 1010 VLLAEAGVPY 1020 DIVLEMDEIN 1030 HDFPDTDLVL 1040 VIGANDTVNS 1050 AAQEDPNSII 1060 AGMPVLEVWK 1070 SKQVIVMKRS 1080 LGVGYAAVDN 1090 PIFYKPNTAM 1100 LLGDAKKTCD 1110 ALQAKVRESY QK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Molecular Function GO:0016491 oxidoreductase activity
Molecular Function GO:0008750 proton-translocating NAD(P)+ transhydrogenase activity

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.