Overview
| Uniprot ID | A0A287B1V1 |
|---|
| Protein Name | Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial |
|---|
| Gene Name | ACADSB |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 292 |
YAIQSLNKGRIGIAA |
Function
Short and branched chain specific acyl-CoA dehydrogenase that catalyzes the proR-proR stereospecific alpha,beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). Among the different mitochondrial acyl-CoA dehydrogenases, acts specifically on short and branched chain acyl-CoA derivatives such as (S)-2-methylbutyryl-CoA as well as short straight chain acyl-CoAs such as butyryl-CoA (butanoyl-CoA). Plays an important role in the metabolism of L-isoleucine by catalyzing the dehydrogenation of 2-methylbutyryl-CoA, one of the steps of the L-isoleucine catabolic pathway. Can also act on valproyl-CoA, a metabolite of valproic acid, an antiepileptic drug
Protein Sequence
10
HAGQAGTLCS
20
CGCPCLRTNF
30
PTCLSSWKHP
40
PRVLKSSQPA
50
PLKTTNNGLS
60
YSPLQTFTDE
70
EMMIKNTVKK
80
FAQEQIAPLV
90
SKMDENSKME
100
KSVIEGLFQQ
110
GLMGIETEPK
120
YGGTGASFFS
130
SVLVIEELAK
140
VDASVALVCD
150
LQNTVINDLI
160
GRFGTEAQKA
170
TYLTKLATEQ
180
LGSFCLSEPS
190
AGSDSFSLKT
200
RADKDGDYYV
210
INGSKMWITS
220
AEDAGLFLVM
230
ANVDPALGYK
240
GITCFLVDRD
250
TEGLRVGKPE
260
NKLGIRASST
270
CPVTLENAKV
280
PEANIVGQIG
290
HGYKYAIQSL
300
NKGRIGIAAQ
310
MLGLAQGCFD
320
LTIPYLKERV
330
QFGKRIFDFQ
340
GLQHQVAHTA
350
TQLEAARLLT
360
YNAARLLEAG
370
RPFIKEASMA
380
KYYASEVAIQ
390
TTNKCIEWMG
400
AVGYTKDYPM
410
EKYFRDAKIG
420
TIYEGTSNIQ
430
LNTIAKNVSK
EY
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005759 |
mitochondrial matrix |
| Molecular Function |
GO:0050660 |
flavin adenine dinucleotide binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0003853 |
short-chain 2-methyl fatty acyl-CoA dehydrogenase activity |
| Biological Process |
GO:0006631 |
fatty acid metabolic process |
| Biological Process |
GO:0006550 |
L-isoleucine catabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.