Search Results
Overview
| Uniprot ID | A0A287B2C5 |
|---|---|
| Protein Name | SUMO-activating enzyme subunit 2 |
| Gene Name | UBA2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 194 | SNEDGDIKRISTKEW |
| 211 | STGYDPVKLFTKLKD |
| 273 | DQQVLDVKSYARLFS |
| 281 | SYARLFSKSIETLRV |
| 377 | CRTIFLNKQPNPKKK |
| 424 | TVLTLQDKIVKEKFA |
| 462 | TEANNHKKLAEFGIR |
| 580 | EKENVSAKRSRIEQT |
| 65 | NRQFLFQKKHVGRSK |
| 77 | RSKAQVAKESVLQFY |
Function
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2
Protein Sequence
10
MALSRGLPRE
20
LAEAVAGGRV
30
LVVGAGGIGC
40
ELLKNLVLTG
50
FSHIDLIDLD
60
TIDVSNLNRQ
70
FLFQKKHVGR
80
SKAQVAKESV
90
LQFYPKANII
100
AYHDSIMNPD
110
YNVEFRQFIL
120
VMNALDNRAA
130
RNHVNRMCLA
140
ADVPLIESGT
150
AGYLGQVTTI
160
KKQLFGEEDA
170
DQEVSPDRAD
180
PEASWEPMEA
190
EARARASNED
200
GDIKRISTKE
210
WAKSTGYDPV
220
KLFTKLKDDI
230
RYLLTMDKLW
240
RKRKPPVPLD
250
WAEVQSQGEE
260
TNASDQQNEP
270
QLGLKDQQVL
280
DVKSYARLFS
290
KSIETLRVHL
300
AEKGDGAELI
310
WDKDDPSAMD
320
FVTSAANLRM
330
HIFSMNMKSR
340
FDIKSMAGNI
350
IPAIATTNAV
360
IAGLIVLEGL
370
KILSGKIDQC
380
RTIFLNKQPN
390
PKKKLLVPCA
400
LDPPNPNCYV
410
CASKPEVTVR
420
LNVHKVTVLT
430
LQDKIVKEKF
440
AMVAPDVQIE
450
DGKGTILISS
460
EEGETEANNH
470
KKLAEFGIRN
480
GSRLQADDFL
490
QDYTLLINIL
500
HSEDLGKDVE
510
FEVVGDAPEK
520
VGPKQTEDAA
530
KSITNGSDDG
540
AQPSTSTAQE
550
QDDVLIVDSD
560
EEGPSNNADI
570
SEEERSRKRK
580
LEEKENVSAK
590
RSRIEQTEEL
DDVIALD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0031510 | SUMO activating enzyme complex |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0019948 | SUMO activating enzyme activity |
| Molecular Function | GO:0016740 | transferase activity |
| Biological Process | GO:0016925 | protein sumoylation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.