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Overview

Uniprot IDA0A287B2K4
Protein NameNeuropilin
Gene NameNRP2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
233 IGKYCGTKTPSELRS

Function

High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF

Protein Sequence

10 MDMFPLTWIF 20 LALYFSGLQV 30 TGQPDPPCGG 40 RLNSKDAGYI 50 TSPGYPQDYP 60 SHQNCEWIVY 70 APEPNQKIVL 80 NFNPHFEIEK 90 HDCKYDFIEI 100 RDGDSESADL 110 LGKHCGNIAP 120 PTIISSGSVL 130 YIKFTSDYAR 140 QGAGFSLRYE 150 IFKTGSEDCS 160 KNFTSPNGTI 170 ESPGFPEKYP 180 HNLDCTFTIL 190 AKPKMEIILQ 200 FLTFDLEHDP 210 LQVGEGDCKY 220 DWLDIWDGIP 230 HVGPLIGKYC 240 GTKTPSELRS 250 ATGILSLTFH 260 TDMAVAKDGF 270 SARYYLVPQE 280 PQDNFQCNVP 290 LGMESGRIAN 300 EQISASSSYS 310 DGRWTPQQSR 320 LHGDDNGWTP 330 NLDSSKEYLQ 340 VDLRFLTVLT 350 AIATQGAISR 360 ETQNGYYVKS 370 YKLEVSTNGE 380 DWMVYRHGKN 390 HKVFQANNDA 400 SEVVLNKLHA 410 PLLTRFVRVR 420 PQTWHAGIAL 430 RLELFGCRVT 440 DAPCSNMLGM 450 LSGLIADSQI 460 SASSTREYLW 470 SPSAARLVSS 480 RSGWFPRIPQ 490 AQPGEEWLQV 500 DLGAPKTVKG 510 VIIQGARGGD 520 SITAVEARAF 530 VRKFKVAYSL 540 NGKDWEHIQD 550 PRTQQPKLFE 560 GNMHYDTPDI 570 RRFDPVPAQY 580 VRVYPERWSP 590 AGIGMRLEVL 600 GCDWTDSKPT 610 VETLGPTVKS 620 EETTTPYPID 630 EEATECGENC 640 SFEDDKDLQL 650 PSGFNCNFDF 660 PEEPCGWVYD 670 HAKWLRSTWT 680 SSSSPSDRTF 690 PDDRNFLRLQ 700 SDGRREGQYA 710 RLISPPVHLP 720 RSPVCMEFQY 730 QATGGRGVAL 740 QVVREASQES 750 KLLWVIREDQ 760 GSEWKHGRII 770 LPSYDMEYQI 780 VFEGVIGKGR 790 SGEIAIDDIR 800 ISTDVPLENC 810 MEPISAFAGG 820 TLLPGTEPTV 830 DTVPVQPIPA 840 YWYYVMAAGG 850 AVLVLVSVAL 860 ALVLHYHRFR 870 YAAKKTDHSI 880 TYKTSHYTNG 890 APLAVEPTLT 900 IKLEQDRSSH C

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016020 membrane
Molecular Function GO:0008201 heparin binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0017154 semaphorin receptor activity
Molecular Function GO:0005021 vascular endothelial growth factor receptor activity
Biological Process GO:0001525 angiogenesis
Biological Process GO:0007411 axon guidance

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.