Search Results
Overview
| Uniprot ID | A0A287B2N2 |
|---|---|
| Protein Name | Amyloid-beta A4 protein |
| Gene Name | APP |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 100 | KRSRKQCKTHTHIVI |
| 128 | LLVPDKCKFLHQERM |
| 54 | ESDPSGTKTCIGTKE |
Function
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis
Protein Sequence
10
VDQSEGLAQF
20
ISCVPTDGNA
30
GLLAEPQVAM
40
FCGKLNMHMN
50
VQNGKWESDP
60
SGTKTCIGTK
70
EGILQYCQEV
80
YPELQITNVV
90
EANQPVTIQN
100
WCKRSRKQCK
110
THTHIVIPYR
120
CLVGEFVSDA
130
LLVPDKCKFL
140
HQERMDVCET
150
HLHWHTVAKE
160
TCSEKSTNLH
170
DYGMLLPCGI
180
DKFRGVEFVC
190
CPLAEESDNI
200
DSADAEEDDS
210
DVWWGGADTD
220
YADGSEDKVV
230
EVAEEEEVAD
240
VEEEEAEDDE
250
DDEDGDEVEE
260
EAEEPYEEAT
270
ERTTSIATTT
280
TTTTESVEEV
290
VREVCSEQAE
300
TGPCRAMISR
310
WYFDVTEGKC
320
APFFYGGCGG
330
NRNNFDTEEY
340
CMAVCGSVIP
350
TTAASTPDAV
360
DKYLETPGDE
370
NEHAHFQKAK
380
ERLEAKHRER
390
MSQVMREWEE
400
AERQAKNLPK
410
ADKKAVIQHF
420
QEKVESLEQE
430
AANERQQLVE
440
THMARVEAML
450
NDRRRLALEN
460
YITALQAVPP
470
RPRHVFNMLK
480
KYVRAEQKDR
490
QHTLKHFEHV
500
RMVDPKKAAQ
510
IRSQVMTHLR
520
VIYERMNQSL
530
SLLYNVPAVA
540
EEIQDEVDEL
550
LQKEQNYSDD
560
VLANMISEPR
570
ISYGNDALMP
580
SLTETKTTVE
590
LLPVNGEFSL
600
DDLQPWHPFG
610
VDSVPANTEN
620
EVEPVDARPA
630
ADRGLTTRPG
640
SGLTNIKTEE
650
ISEVKMDAEF
660
RHDSGYEVHH
670
QKLVFFAEDV
680
GSNKGAIIGL
690
MVGGVVIATV
700
IVITLVMLKK
710
KQYTSIHHGV
720
VEVDAAVTPE
730
ERHLSKMQQN
740
GYENPTYKFF
EQMQN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005905 | clathrin-coated pit |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0005798 | Golgi-associated vesicle |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0099503 | secretory vesicle |
| Molecular Function | GO:0008201 | heparin binding |
| Molecular Function | GO:0140677 | molecular function activator activity |
| Molecular Function | GO:0004867 | serine-type endopeptidase inhibitor activity |
| Molecular Function | GO:0046914 | transition metal ion binding |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0006897 | endocytosis |
| Biological Process | GO:0007219 | Notch signaling pathway |
| Biological Process | GO:0010604 | positive regulation of macromolecule metabolic process |
| Biological Process | GO:0051246 | regulation of protein metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.