Search Results

Overview

Uniprot IDA0A287B2T9
Protein NameCold shock domain-containing protein E1
Gene NameCSDE1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
132 TGKPIAVKLVKIKQE
212 NFVIDNNKHTGAVSA
323 VIPKVPSKNQNDPLP
480 RFLGTVEKEATFSNP
624 GNKVSAEKVSKTHSV
694 NKGDCLQKGESVKFQ
789 WRVCEGPKAVAAPRP
804 DRLVNRLKNITLDDA

Function

RNA-binding protein involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Required for efficient formation of stress granules

Protein Sequence

10 MENVFTVSSD 20 PHPPPATPPS 30 LSLPLSSSST 40 SSGTKKQKRT 50 PTYQRSMSFD 60 PNLLHNNGHN 70 GYPNGTSAAL 80 RETGVIEKLL 90 TSYGFIQCSE 100 RQARLFFHCS 110 QYNGNLQDLK 120 VGDDVEFEVS 130 SDRRTGKPIA 140 VKLVKIKQEI 150 LPEERINGQV 160 VCAVPHNLES 170 KSPAAPGQSP 180 TGSVCYERNG 190 EVFYLTYTPE 200 DVEGNVQLET 210 GDKINFVIDN 220 NKHTGAVSAR 230 NIMLLKKKQA 240 RCQGVVCAMK 250 EAFGFIERGD 260 VVKEIFFHYS 270 EFKGDLETLQ 280 PGDDVEFTIK 290 DRNGKEVATD 300 VRLLPQGTVI 310 FEDISIEHFE 320 GTVTKVIPKV 330 PSKNQNDPLP 340 GRIKVDFVIP 350 KELPFGDKDT 360 KSKVTLLEGD 370 HVRFNISTDR 380 RDKLERATNI 390 EVLSNTFQFT 400 NEAREMGVIA 410 AMRDGFGFIK 420 CVDRDARMFF 430 HFSEILDGNQ 440 LHIADEVEFT 450 VVPDMLSAQR 460 NHAIRIKKLP 470 KGTVSFHSHS 480 DHRFLGTVEK 490 EATFSNPKTT 500 SPNKGKEKEA 510 EDGVIAYDDC 520 GVKLTIAFQA 530 KDVEGSTSPQ 540 IGDKVEFSIS 550 DKQRPGQQIA 560 TCVRLLGRNS 570 NSKRLLGYVA 580 TLKDNFGFIE 590 TANHDKEIFF 600 HYSEFSGDVD 610 SLELGDMVEY 620 SLSKGKGNKV 630 SAEKVSKTHS 640 VNGITEEADP 650 TIYSGKVIRP 660 LRSVDPTQTE 670 YQGMIEIVEE 680 GDMKGEVYPF 690 GIVGMANKGD 700 CLQKGESVKF 710 QLCVLGQNAQ 720 TMAYNITPLR 730 RATVECVKDQ 740 FGFINYEVGD 750 SKKLFFHVKE 760 VQDGIELQAG 770 DEVEFSVILN 780 QRTGKCSACN 790 VWRVCEGPKA 800 VAAPRPDRLV 810 NRLKNITLDD 820 ASAPRLMVLR 830 QPRGPDNSMG 840 FGAERKIRQA GVID

Gene Ontology

Classification GO ID Description
Cellular Component GO:0070937 CRD-mediated mRNA stability complex
Cellular Component GO:0010494 cytoplasmic stress granule
Cellular Component GO:0106002 mCRD-mediated mRNA stability complex
Cellular Component GO:0000932 P-body
Molecular Function GO:0106222 lncRNA binding
Molecular Function GO:0140517 protein-RNA adaptor activity
Molecular Function GO:1905172 RISC complex binding
Molecular Function GO:0035613 RNA stem-loop binding
Biological Process GO:0070934 CRD-mediated mRNA stabilization
Biological Process GO:0075522 IRES-dependent viral translational initiation
Biological Process GO:1900152 negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Biological Process GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay
Biological Process GO:2000767 positive regulation of cytoplasmic translation
Biological Process GO:0034063 stress granule assembly

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.