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Overview

Uniprot ID	A0A287B2W0
Protein Name	Multifunctional fusion protein
Gene Name	ALDH4A1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
144	SPFNHGHKVAKFCYA
153	AKFCYADKALLHRAI
168	EAALAARKEWDLKPV
372	LAGECGGKNFHFVHR

Function

Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes

Protein Sequence

10 MGSEEAGHMT 20 KDTRWQDLNL 30 NLGFGLRGWF 40 SSPCSIVALD 50 FKIPGQSRTP 60 VRNRGWDWRW 70 LLLTCPPLFL 80 PLVPRLCWKH 90 ISSLEVANEP 100 VLTFTQGSPE 110 RDALRKALKE 120 LKGRTEAIPC 130 VVGDEEVWTS 140 DVRYQVSPFN 150 HGHKVAKFCY 160 ADKALLHRAI 170 EAALAARKEW 180 DLKPVADRAQ 190 VFLKAADMLS 200 GPRRAEILAK 210 TMVGQGKTVI 220 QAEIDAAAEL 230 IDFFRFNAKF 240 AVELEGQQPI 250 SVPPSTNSVV 260 YRGLEGFVAA 270 ISPFNFTAIG 280 GNLAGAPALM 290 GNVVLWKPSD 300 TAMLASYAVY 310 RVLREAGLPP 320 NIIQFVPADG 330 PTFGDTVTSS 340 EHLCGINFTG 350 SVPTFKHLWK 360 QVAQNLDHFR 370 TFPRLAGECG 380 GKNFHFVHRS 390 ADVDSVVSGT 400 LRSAFEYGGQ 410 KCSACSRLYV 420 PGSLWPQIKG 430 RLLEEHGRIK 440 VGDSFGRIRK 450 WLEHARSSPS 460 LTILAGGQCD 470 DSVGYFVEPC 480 IIESKDPQEP 490 IMKEEIFGPL 500 LTVYVYPDDK 510 YKETLRLVDS 520 TTSYGLTGQC 530 LPRISELPQP 540 LCSIPGVLSP 550 TGPCCPRRLL 560 PWTWILVIML 570 PLLSIHCPDP 580 WAGLPNTDRP RQQALC

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Molecular Function	GO:0003842	L-glutamate gamma-semialdehyde dehydrogenase activity
Biological Process	GO:0010133	L-proline catabolic process to L-glutamate

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.