Search Results
Overview
| Uniprot ID | A0A287B3D7 |
|---|---|
| Protein Name | Core histone macro-H2A |
| Gene Name | MACROH2A1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 134 | IITPPPAKKAKSPSQ |
| 18 | TKTSRSAKAGVIFPV |
| 282 | SPVWGADKCEELLEK |
| 292 | ELLEKTVKNCLALAD |
| 301 | CLALADDKKLKSIAF |
| 304 | LADDKKLKSIAFPSI |
Function
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes
Protein Sequence
10
MSSRGGKKKS
20
TKTSRSAKAG
30
VIFPVGRMLR
40
YIKKGHPKYR
50
IGVGAPVYMA
60
AVLEYLTAEI
70
LELAGNAARD
80
NKKGRVTPRH
90
ILLAVANDEE
100
LNQLLKGVTI
110
ASGGVLPNIH
120
PELLAKKRGS
130
KGKLEAIITP
140
PPAKKAKSPS
150
QKKPVSKKTG
160
GKKGARKSKK
170
KQGEVSKAAS
180
ADSTTEGTPA
190
DGFTVLSTKS
200
LFLGQKLQVV
210
QADIASIDSD
220
AVVHPTNTDF
230
YTGGEVGNTL
240
EKKGGKEFVE
250
AVLELRKKNG
260
PLEVAGAAVS
270
AGHGLPAKFV
280
IHCNSPVWGA
290
DKCEELLEKT
300
VKNCLALADD
310
KKLKSIAFPS
320
IGSGRNGFPK
330
QTAAQLILRA
340
ISSYFVSTMS
350
SSIKTVYFVL
360
FDSESIGIYV
QEMAKLDAN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000786 | nucleosome |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0031490 | chromatin DNA binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0030527 | structural constituent of chromatin |
| Biological Process | GO:0031507 | heterochromatin formation |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:1901837 | negative regulation of transcription of nucleolar large rRNA by RNA polymerase I |
| Biological Process | GO:0006334 | nucleosome assembly |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.