Search Results
Overview
| Uniprot ID | A0A287B3I9 |
|---|---|
| Protein Name | Cellular tumor antigen p53 |
| Gene Name | TP53 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 121 | FLHSGTAKSVTCTYS |
| 293 | TEEENFLKKGQSCPE |
| 294 | EEENFLKKGQSCPEP |
| 321 | TSSSPVQKKKPLDGE |
Function
Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression
Protein Sequence
10
MEESQSELGV
20
EPPLSQETFS
30
DLGLGGWGAG
40
LLTPVVPIHP
50
QSSELSLAAV
60
NDLLLSPVTN
70
WLDENPDDAS
80
RVPAPPAATA
90
PAPAAPAPAT
100
SWPLSSFVPS
110
QKTYPGSYDF
120
RLGFLHSGTA
130
KSVTCTYSPA
140
LNKLFCQLAK
150
TCPVQLWVSS
160
PPPPGTRVRA
170
MAIYKKSEYM
180
TEVVRRCPHH
190
ERSSDYSDGL
200
APPQHLIRVE
210
GNLRAEYLDD
220
RNTFRHSVVV
230
PYEPPEVGSD
240
CTTIHYNFMC
250
NSSCMGGMNR
260
RPILTIITLE
270
DASGNLLGRN
280
SFEVRVCACP
290
GRDRRTEEEN
300
FLKKGQSCPE
310
PPPGSTKRAL
320
PTSTSSSPVQ
330
KKKPLDGEYF
340
TLQIRGRERF
350
EMFRELNDAL
360
ELKDAQTARE
370
SGENRAHSSH
380
LKSKKGQSPS
390
RHKKPMFKRE
GPDSD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Molecular Function | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding |
| Molecular Function | GO:0001094 | TFIID-class transcription factor complex binding |
| Molecular Function | GO:0001223 | transcription coactivator binding |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0006914 | autophagy |
| Biological Process | GO:0048539 | bone marrow development |
| Biological Process | GO:0072717 | cellular response to actinomycin D |
| Biological Process | GO:0071480 | cellular response to gamma radiation |
| Biological Process | GO:0071456 | cellular response to hypoxia |
| Biological Process | GO:0034644 | cellular response to UV |
| Biological Process | GO:0071466 | cellular response to xenobiotic stimulus |
| Biological Process | GO:0048512 | circadian behavior |
| Biological Process | GO:0008340 | determination of adult lifespan |
| Biological Process | GO:0030330 | DNA damage response, signal transduction by p53 class mediator |
| Biological Process | GO:0043153 | entrainment of circadian clock by photoperiod |
| Biological Process | GO:0060218 | hematopoietic stem cell differentiation |
| Biological Process | GO:0008104 | intracellular protein localization |
| Biological Process | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| Biological Process | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| Biological Process | GO:0031571 | mitotic G1 DNA damage checkpoint signaling |
| Biological Process | GO:0009299 | mRNA transcription |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0030308 | negative regulation of cell growth |
| Biological Process | GO:0048147 | negative regulation of fibroblast proliferation |
| Biological Process | GO:1903451 | negative regulation of G1 to G0 transition |
| Biological Process | GO:1905856 | negative regulation of pentose-phosphate shunt |
| Biological Process | GO:0032211 | negative regulation of telomere maintenance via telomerase |
| Biological Process | GO:0006289 | nucleotide-excision repair |
| Biological Process | GO:0097252 | oligodendrocyte apoptotic process |
| Biological Process | GO:0090403 | oxidative stress-induced premature senescence |
| Biological Process | GO:2000774 | positive regulation of cellular senescence |
| Biological Process | GO:1900119 | positive regulation of execution phase of apoptosis |
| Biological Process | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway |
| Biological Process | GO:1902895 | positive regulation of miRNA transcription |
| Biological Process | GO:0062100 | positive regulation of programmed necrotic cell death |
| Biological Process | GO:2000379 | positive regulation of reactive oxygen species metabolic process |
| Biological Process | GO:0090200 | positive regulation of release of cytochrome c from mitochondria |
| Biological Process | GO:0045899 | positive regulation of RNA polymerase II transcription preinitiation complex assembly |
| Biological Process | GO:0070245 | positive regulation of thymocyte apoptotic process |
| Biological Process | GO:0051262 | protein tetramerization |
| Biological Process | GO:0007265 | Ras protein signal transduction |
| Biological Process | GO:0090399 | replicative senescence |
| Biological Process | GO:0045815 | transcription initiation-coupled chromatin remodeling |
| Biological Process | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| Biological Process | GO:0060333 | type II interferon-mediated signaling pathway |
| Biological Process | GO:0016032 | viral process |
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0016605 | PML body |
| Cellular Component | GO:0005667 | transcription regulator complex |
| Molecular Function | GO:0036310 | ATP-dependent DNA/DNA annealing activity |
| Molecular Function | GO:0005507 | copper ion binding |
| Molecular Function | GO:0001046 | core promoter sequence-specific DNA binding |
| Molecular Function | GO:0097718 | disordered domain specific binding |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function | GO:0042826 | histone deacetylase binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0097371 | MDM2/MDM4 family protein binding |
| Molecular Function | GO:0140693 | molecular condensate scaffold activity |
| Molecular Function | GO:0140677 | molecular function activator activity |
| Molecular Function | GO:0003730 | mRNA 3'-UTR binding |
| Molecular Function | GO:0002039 | p53 binding |
| Molecular Function | GO:1990841 | promoter-specific chromatin binding |
| Molecular Function | GO:0002020 | protease binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0051721 | protein phosphatase 2A binding |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Molecular Function | GO:0030971 | receptor tyrosine kinase binding |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.