Search Results
Overview
| Uniprot ID | A0A287B3J0 |
|---|---|
| Protein Name | Porphobilinogen deaminase |
| Gene Name | HMBS |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 53 | ILDTALSKIGEKSLF |
Function
As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen. Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled. In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact
Protein Sequence
10
MRVIRVGTRK
20
SQLARIQTDS
30
VVATLKALYP
40
GLQFEIIAMS
50
TTGDKILDTA
60
LSKIGEKSLF
70
TKELEHALER
80
NEVDLVVHSL
90
KDLPTVLPPG
100
FTIGAVCKRE
110
CPYDAVVFHP
120
KFVGKTLETL
130
PEKSVVGTSS
140
LRRAAQLQRK
150
FPHLEFKSIR
160
GNLNTRLRKL
170
DELQEFSAII
180
LAAAGLQRMG
190
WQNRVGQILH
200
PEECMYAVGQ
210
GALGVEVRAK
220
DQDILDLVGV
230
LHDPETLLRC
240
IAERAFLRHL
250
EGGCSVPVAV
260
HTAMKDGQLY
270
LTGGVWSLNG
280
AESMQETMQA
290
TIHVPAQHED
300
GPEDDPQLVG
310
ITARNIPREA
320
QLAAENLGIS
330
LATLLLNKGA
340
KNILDVARQL
NDAH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0004418 | hydroxymethylbilane synthase activity |
| Biological Process | GO:0006782 | protoporphyrinogen IX biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.